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Tbio
LHX5
LIM/homeobox protein Lhx5

Protein Summary
Description
Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system. This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development. This protein is involved in learning and motor functions in adult mice. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261731
  • ENSP00000261731
  • ENSG00000089116
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
biological process
0.64
PubMedID
0.63
protein domain
0.58
transcription factor binding site profile
0.56


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.15   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.15   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM homeobox 5
VGNC:5452
740060
Mouse
MGI:107792
16873
Rat
RGD:71079
124451
Dog
LIM homeobox 5
VGNC:42666
486283
Horse
LIM homeobox 5
VGNC:19659
100056306
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM homeobox 5
Mouse
Rat
Dog
LIM homeobox 5
Horse
LIM homeobox 5
Pathways (42)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Signaling pathways regulating pluripotency of stem cells
Name
Explore in Pharos
Explore in Source
Signaling pathways regulating pluripotency of stem cells
Protein-Protein Interactions (55)
1 – 10 of 55
LBX1
Tbio
Family: TF
Novelty: 0.00550999
Score: 0.785
Data Source: STRINGDB
CCNK
Tbio
Novelty: 0.03528971
Score: 0.762
Data Source: STRINGDB
DBX1
Tbio
Family: TF
Novelty: 0.02105514
Score: 0.695
Data Source: STRINGDB
EMX1
Tbio
Family: TF
Novelty: 0.00584996
Score: 0.621
Data Source: STRINGDB
TBR1
Tbio
Family: TF
Novelty: 0.00676736
Score: 0.613
Data Source: STRINGDB
BARHL2
Tbio
Family: TF
Novelty: 0.09447868
Score: 0.602
Data Source: STRINGDB
LDB1
Tbio
Novelty: 0.01110112
Score: 0.598
Data Source: STRINGDB
EMX2
Tbio
Family: TF
Novelty: 0.0064759
Score: 0.597
Data Source: STRINGDB
ZBTB20
Tbio
Family: TF
Novelty: 0.01694308
Score: 0.593
Data Source: STRINGDB
WNT8B
Tbio
Novelty: 0.0140304
Score: 0.578
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.15

PubMed score by year
PubTator Score  4.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer