Tbio SYT4 Synaptotagmin-4

Protein Summary

Description

May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Uniprot Accession IDs

• Q9H2B2
• B4DEU3
• Q9P2K4

Gene Name

• SYT4

Ensembl ID

• ENST00000255224
• ENSP00000255224
• ENSG00000132872
• ENST00000590752
• ENSP00000466930

Symbol

• KIAA1342
• HsT1192

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.72
cellular component	0.7
molecular function	0.63
PubMedID	0.6
gene perturbation	0.52

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Synaptotagmin-4

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Synaptotagmin-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.1   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 314   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.1   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0