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Tbio
NEUROG2
Neurogenin-2

Protein Summary
Description
Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313341
  • ENSP00000317333
  • ENSG00000178403

Symbol
  • ATOH4
  • BHLHA8
  • NGN2
  • NGN2
  • Atoh4
  • ngn-2
  • Math4A
  • bHLHa8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
biological process
0.74
transcription factor binding site profile
0.68
histone modification site profile
0.65
PubMedID
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.76   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.76   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neurogenin 2
701345
Mouse
MGI:109619
11924
Rat
RGD:1309061
295475
Dog
neurogenin 2
VGNC:43757
100683455
Cow
neurogenin 2
VGNC:32022
615555
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neurogenin 2
Mouse
Rat
Dog
neurogenin 2
Cow
neurogenin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H2A3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (122)
1 – 10 of 122
PAX6
Tbio
Family: TF
Novelty: 0.00064695
Score: 0.95
Data Source: STRINGDB
ASCL1
Tbio
Family: TF
Novelty: 0.00274239
Score: 0.922
Data Source: STRINGDB
NR4A2
Tchem
Family: NR
Novelty: 0.00204712
Score: 0.804
Data Source: STRINGDB
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.761
Data Source: STRINGDB
DLL1
Tbio
Novelty: 0.00150384
Score: 0.706
Data Source: STRINGDB
POU3F2
Tbio
Family: TF
Novelty: 0.00649458
Score: 0.7
Data Source: STRINGDB
LMX1A
Tbio
Family: TF
Novelty: 0.0104588
Score: 0.695
Data Source: STRINGDB
DLX2
Tbio
Family: TF
Novelty: 0.00609908
Score: 0.689
Data Source: STRINGDB
HES5
Tbio
Family: TF
Novelty: 0.00565225
Score: 0.687
Data Source: STRINGDB
ISL1
Tbio
Family: TF
Novelty: 0.00169431
Score: 0.686
Data Source: STRINGDB
Publication Statistics
PubMed Score  213.76

PubMed score by year
PubTator Score  89.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer