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Tbio
ALDH8A1
Aldehyde dehydrogenase family 8 member A1

Protein Summary
Description
Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro). This gene encodes a member of the aldehyde dehydrogenase family of proteins. The encoded protein has been implicated in the synthesis of 9-cis-retinoic acid and in the breakdown of the amino acid tryptophan. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. In addition, this enzyme has been shown to catalyze the conversion of 2-aminomuconic semialdehyde to 2-aminomuconate in the kynurenine pathway of tryptophan catabolism. [provided by RefSeq, Jul 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265605
  • ENSP00000265605
  • ENSG00000118514
  • ENST00000349305
  • ENSP00000325473
  • ENST00000367845
  • ENSP00000356819
  • ENST00000367847
  • ENSP00000356821

Symbol
  • ALDH12
  • ALDH12
  • DJ352A20.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
tissue sample
0.63
kinase perturbation
0.6
gene perturbation
0.59
cell line
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.63   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.63   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (86)
1 – 10 of 86
ALDH6A1
Tbio
Family:  Enzyme
Novelty:  0.03785268
p_int:  0.999999384
p_ni:  6.16e-7
Score:  0.658
Data Source:  BioPlex,STRINGDB
RPUSD2
Tdark
Family:  Enzyme
Novelty:  1.41606982
p_int:  0.999495913
p_ni:  0.000347355
p_wrong:  0.000156732
Score:  0.525
Data Source:  BioPlex,STRINGDB
ADHFE1
Tbio
Family:  Enzyme
Novelty:  0.04122373
Score:  0.763
Data Source:  STRINGDB
ALDH18A1
Tbio
Family:  Enzyme
Novelty:  0.00301673
Score:  0.762
Data Source:  STRINGDB
PDE7B
Tclin
Family:  Enzyme
Novelty:  0.04895806
Score:  0.745
Data Source:  STRINGDB
AHI1
Tbio
Novelty:  0.01180688
Score:  0.733
Data Source:  STRINGDB
HBS1L
Tbio
Novelty:  0.00125579
Score:  0.724
Data Source:  STRINGDB
STS
Tchem
Family:  Enzyme
Novelty:  0.00324549
Score:  0.722
Data Source:  STRINGDB
HGD
Tbio
Family:  Enzyme
Novelty:  0.01924565
Score:  0.687
Data Source:  STRINGDB
VCPIP1
Tbio
Novelty:  0.09915033
Score:  0.676
Data Source:  STRINGDB
Pathways (7)
RA biosynthesis pathway (R-HSA-5365859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RA biosynthesis pathway
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Reactome
Signaling by Retinoic Acid
Name
Explore in Pharos
Explore in Source
RA biosynthesis pathway
Signal Transduction
Signaling by Nuclear Receptors
Signaling by Retinoic Acid
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
4
6
97.1
reticulocyte measurement
3
2
3
89.1
erythrocyte count
2
2
2
86.8
platelet crit
1
1
1
78.1
mean reticulocyte volume
1
1
1
73
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
97.1
reticulocyte measurement
3
89.1
erythrocyte count
2
86.8
platelet crit
1
78.1
mean reticulocyte volume
1
73
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 8 family member A1
VGNC:7162
746950
Macaque
aldehyde dehydrogenase 8 family member A1
712386
Mouse
MGI:2653900
237320
Rat
RGD:1590218
685750
Dog
aldehyde dehydrogenase 8 family member A1
VGNC:37790
476210
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 8 family member A1
Macaque
aldehyde dehydrogenase 8 family member A1
Mouse
Rat
Dog
aldehyde dehydrogenase 8 family member A1
Publication Statistics
PubMed Score 9.63
PubMed score by year
PubTator Score 4.19
PubTator score by year