Tbio SH3BGRL3 SH3 domain-binding glutamic acid-rich-like protein 3

Protein Summary

Description

Could act as a modulator of glutaredoxin biological activity.

Uniprot Accession IDs

• Q9H299
• Q5T122

Gene Name

• SH3BGRL3

Ensembl ID

• ENST00000270792
• ENSP00000270792
• ENSG00000142669

Symbol

• TIP-B1
• SH3BP-1
• HEL-S-297

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.87
transcription factor perturbation	0.8
transcription factor binding site profile	0.77
kinase perturbation	0.71
gene perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.76   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.76   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0