Tbio IL25 Interleukin-25

Protein Summary

Description

Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses. The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q9H293
• Q2M3F0
• Q8IZV3
• Q8WXB0
• IL-25

Gene Name

• IL25

Ensembl ID

• ENST00000329715
• ENSP00000328111
• ENSG00000166090
• ENST00000397242
• ENSP00000380417

Symbol

• IL17E
• IL17E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.6
biological term	0.55
cell line	0.54
biological process	0.51
phenotype	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.97   (req: < 5)

Gene RIFs: 91   (req: <= 3)

Antibodies: 645   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.97   (req: >= 5)

Gene RIFs: 91   (req: > 3)

Antibodies: 645   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0