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Tbio
VPS16
Vacuolar protein sorting-associated protein 16 homolog

Protein Summary
Description
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for recruitment of VPS33A to the HOPS complex (PubMed:23901104). Required for fusion of endosomes and autophagosomes with ly ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380445
  • ENSP00000369810
  • ENSG00000215305
  • ENST00000380469
  • ENSP00000369836

Symbol
  • hVPS16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
cellular component
0.86
interacting protein
0.85
disease perturbation
0.79
transcription factor
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.38   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.38   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
1
1
21
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
21
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
Ebola Virus Pathway on Host
Name
Explore in Pharos
Explore in Source
Ebola Virus Pathway on Host
Ebola Virus Pathway on Host
Ebola Virus Pathway on Host
Ebola Virus Pathway on Host
Ebola Virus Pathway on Host
Gene Ontology Terms (21)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (133)
1 – 10 of 133
VPS33A
Tbio
Novelty: 0.08316241
p_int: 0.99999665
p_ni: 0.00000335
Score: 0.999
Data Source: BioPlex,STRINGDB
VPS41
Tbio
Novelty: 0.08480171
p_int: 0.999994499
p_ni: 0.000005501
Score: 0.999
Data Source: BioPlex,STRINGDB
TECPR2
Tbio
Novelty: 0.11606334
p_int: 0.996990802
p_ni: 0.003009198
Score: 0.819
Data Source: BioPlex,STRINGDB
SRSF2
Tbio
Novelty: 0.00207072
p_int: 0.992274047
p_ni: 0.007725953
Data Source: BioPlex
CT55
Tdark
Novelty: 0.20854606
p_int: 0.969939534
p_ni: 0.030060465
p_wrong: 1e-9
Score: 0.735
Data Source: BioPlex,STRINGDB
PKNOX1
Tbio
Family: TF
Novelty: 0.01063674
p_int: 0.967333483
p_ni: 0.032666517
Score: 0.28
Data Source: BioPlex,STRINGDB
LYPD4
Tbio
Novelty: 0.00381728
p_int: 0.9340124
p_ni: 0.0659876
Data Source: BioPlex
SEMA4C
Tbio
Novelty: 0.01237067
p_int: 0.933517517
p_ni: 0.066482344
p_wrong: 1.39e-7
Data Source: BioPlex
TBC1D4
Tbio
Novelty: 0.00549202
p_int: 0.910570923
p_ni: 0.089429077
Data Source: BioPlex
FAM167A
Tbio
Novelty: 0.05232679
p_int: 0.866468269
p_ni: 0.133531731
Data Source: BioPlex
Publication Statistics
PubMed Score  26.38

PubMed score by year
PubTator Score  5.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer