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Tbio
OR51E2
Olfactory receptor 51E2

Protein Summary
Description
Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). May also function as an olfactory receptor being activated by beta-ionone (PubMed:19389702). Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396950
  • ENSP00000380153
  • ENSG00000167332
  • ENST00000641638
  • ENSP00000493442

Symbol
  • PSGR
  • PSGR
  • HPRAJ
  • OR52A2
  • OR51E3P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.54
phenotype
0.54
disease
0.53
biological process
0.47
cell line
0.47


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.08   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.08   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
olfactory receptor, family 51, subfamily E, member 2
717504
Mouse
MGI:2157548
170639
Rat
RGD:628858
170816
Dog
olfactory receptor family 51 subfamily E member 2 [Source:HGNC Symbol;Acc:HGNC:15195]
Horse
olfactory receptor family 51 subfamily E member 2
VGNC:54744
100067151
Species
Name
OMA
EggNOG
Inparanoid
Macaque
olfactory receptor, family 51, subfamily E, member 2
Mouse
Rat
Dog
olfactory receptor family 51 subfamily E member 2 [Source:HGNC Symbol;Acc:HGNC:15195]
Horse
olfactory receptor family 51 subfamily E member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H255-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Olfactory Signaling Pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (47)
1 – 10 of 47
VSIG8
Tdark
Novelty: 1.16023405
p_int: 0.99911772
p_ni: 0.00088228
Data Source: BioPlex
LRRC15
Tbio
Novelty: 0.03701624
p_int: 0.998552786
p_ni: 0.001447214
Data Source: BioPlex
DSG4
Tbio
Novelty: 0.01599371
p_int: 0.998312709
p_ni: 0.001687269
p_wrong: 2.2e-8
Data Source: BioPlex
HEPHL1
Tbio
Novelty: 0.44678065
p_int: 0.994442652
p_ni: 0.005557348
Data Source: BioPlex
S100A3
Tbio
Novelty: 0.03024004
p_int: 0.991591764
p_ni: 0.000357072
p_wrong: 0.008051164
Score: 0.189
Data Source: BioPlex,STRINGDB
DUSP14
Tbio
Family: Enzyme
Novelty: 0.04013065
p_int: 0.965715864
p_ni: 0.034284126
p_wrong: 1.1e-8
Score: 0.158
Data Source: BioPlex,STRINGDB
CALHM4
Tdark
Family: IC
Novelty: 2.79788039
p_int: 0.945903797
p_ni: 0.003318484
p_wrong: 0.050777719
Score: 0.163
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.879048666
p_ni: 0.120951281
p_wrong: 5.4e-8
Data Source: BioPlex
RTP2
Tbio
Novelty: 0.05972678
Score: 0.953
Data Source: STRINGDB
RTP1
Tbio
Novelty: 0.0278378
Score: 0.948
Data Source: STRINGDB
Publication Statistics
PubMed Score  46.08

PubMed score by year
PubTator Score  24.21

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer