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Tclin
KCNH6
Potassium voltage-gated channel subfamily H member 6

Protein Summary
Description
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000456941
  • ENSP00000396900
  • ENSG00000173826
  • ENST00000580652
  • ENSP00000464672
  • ENST00000581784
  • ENSP00000463830
  • ENST00000583023
  • ENSP00000463533

Symbol
  • ERG2
  • ERG2
  • ERG-2
  • HERG2
  • Kv11.2
  • hERG-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.81
cell type or tissue
0.7
cell line
0.53
tissue
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.56   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.56   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (31)
1 – 10 of 31
KCNH2
Tclin
Family: IC
Novelty: 0.00041611
Score: 0.962
Data Source: STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
Score: 0.932
Data Source: STRINGDB
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
Score: 0.929
Data Source: STRINGDB
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
Score: 0.928
Data Source: STRINGDB
SIGMAR1
Tclin
Novelty: 0.00338804
Score: 0.9
Data Source: STRINGDB
SLC24A3
Tbio
Family: Transporter
Novelty: 0.05923224
Score: 0.674
Data Source: STRINGDB
KCNA4
Tclin
Family: IC
Novelty: 0.00362065
Score: 0.666
Data Source: STRINGDB
EBP
Tchem
Family: Enzyme
Novelty: 0.00610658
Score: 0.641
Data Source: STRINGDB
ERG
Tbio
Family: TF
Novelty: 0.04049734
Score: 0.638
Data Source: STRINGDB
TMBIM4
Tbio
Novelty: 0.00736177
Score: 0.62
Data Source: STRINGDB
Publication Statistics
PubMed Score  81.56

PubMed score by year
PubTator Score  23.79

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer