Protein Summary
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated w ...more
- ENST00000224721
- ENSP00000224721
- ENSG00000107736
- ENST00000398788
- ENSP00000381768
- ENST00000461841
- ENSP00000473454
- ENST00000619887
- ENSP00000478374
- KIAA1774
- KIAA1812
- PITA5
- USH1D
- CDHR23
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.86 | ||
transcription factor | 0.76 | ||
cellular component | 0.69 | ||
phenotype | 0.67 | ||
disease | 0.66 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 188.44 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 250 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 188.44 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 250 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte count | 3 | 2 | 3 | 89.1 | |||||
lymphocyte count | 3 | 1 | 3 | 84.2 | |||||
myeloid white cell count | 3 | 1 | 3 | 83.9 | |||||
neutrophil count | 2 | 1 | 2 | 76 | |||||
progranulin measurement | 1 | 1 | 1 | 67.2 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte count | 3 | 89.1 | |||||
lymphocyte count | 3 | 84.2 | |||||
myeloid white cell count | 3 | 83.9 | |||||
neutrophil count | 2 | 76 | |||||
progranulin measurement | 1 | 67.2 | |||||
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | cadherin related 23 | 709433 | ||||||
Mouse | MGI:1890219 | 22295 | ||||||
Dog | cadherin related 23 | VGNC:50871 | 100684999 | |||||
Cow | cadherin related 23 | 784716 | ||||||
Pig | cadherin related 23 | 100157198 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | cadherin related 23 | |||||
Mouse | ||||||
Dog | cadherin related 23 | |||||
Cow | cadherin related 23 | |||||
Pig | cadherin related 23 | |||||
Protein Structure (6 Structures, 11 AlphaFold Models)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 6
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (5)
PathwayCommons (2)
WikiPathways (3)
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: panther | Cadherin signaling pathway | ||||
PathwayCommons: panther | Wnt signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cadherin signaling pathway | ||||
Wnt signaling pathway | ||||
Gene Ontology Terms (17)
Functions (1)
Components (4)
Processes (12)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (107)
1 – 10 of 107
CD160
Novelty: 0.01511748
p_int: 0.994915452
p_ni: 0.005043698
p_wrong: 0.000040851
Data Source: BioPlex
USH1C
Novelty: 0.01066917
Score: 0.999
Data Source: STRINGDB
MYO7A
Novelty: 0.00314435
Score: 0.968
Data Source: STRINGDB
PCDH15
Novelty: 0.0097699
Score: 0.882
Data Source: STRINGDB
USH1G
Novelty: 0.02912203
Score: 0.882
Data Source: STRINGDB
MYO15A
Novelty: 0.0148787
Score: 0.841
Data Source: STRINGDB
WHRN
Novelty: 0.01886351
Score: 0.839
Data Source: STRINGDB
USH2A
Novelty: 0.00223387
Score: 0.815
Data Source: STRINGDB
TMC1
Family: IC
Novelty: 0.00609628
Score: 0.815
Data Source: STRINGDB
ADGRV1
Family: GPCR
Novelty: 0.01398129
Score: 0.807
Data Source: STRINGDB
Publication Statistics
PubMed Score 188.44
PubMed score by year
PubTator Score 84.94
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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