Protein Summary
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated w ...more
- ENST00000224721
- ENSP00000224721
- ENSG00000107736
- ENST00000398788
- ENSP00000381768
- ENST00000461841
- ENSP00000473454
- ENST00000619887
- ENSP00000478374
- KIAA1774
- KIAA1812
- PITA5
- USH1D
- CDHR23
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.86 | ||
transcription factor | 0.76 | ||
cellular component | 0.69 | ||
phenotype | 0.67 | ||
disease | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 196.09 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 250 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 196.09 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 250 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (107)
CD160
Novelty: 0.01511748
p_int: 0.994915452
p_ni: 0.005043698
p_wrong: 0.000040851
Data Source: BioPlex
Nearest Tclin Targets
Pathways (5)
PathwayCommons (2)
WikiPathways (3)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: panther | Cadherin signaling pathway | ||||
PathwayCommons: panther | Wnt signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cadherin signaling pathway | ||||
Wnt signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (1)
Components (4)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 2 | 4 | 93.9 | |||||
leukocyte count | 3 | 3 | 5 | 85.8 | |||||
myeloid white cell count | 3 | 1 | 3 | 80.9 | |||||
monocyte count | 2 | 1 | 2 | 77.7 | |||||
neutrophil count | 2 | 1 | 2 | 74.8 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 4 | 93.9 | |||||
leukocyte count | 5 | 85.8 | |||||
myeloid white cell count | 3 | 80.9 | |||||
monocyte count | 2 | 77.7 | |||||
neutrophil count | 2 | 74.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | cadherin related 23 | 709433 | ||||||
Mouse | MGI:1890219 | 22295 | ||||||
Dog | cadherin related 23 | VGNC:50871 | 100684999 | |||||
Cow | cadherin related 23 | 784716 | ||||||
Pig | cadherin related 23 | 100157198 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | cadherin related 23 | |||||
Mouse | ||||||
Dog | cadherin related 23 | |||||
Cow | cadherin related 23 | |||||
Pig | cadherin related 23 | |||||
Publication Statistics
PubMed Score 196.09
PubMed score by year
PubTator Score 84.94
PubTator score by year
Related Publications
Text Mined References (67)
GeneRif Annotations (42)
Items per page:
0 of 0
PMID | Year | Title |
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