You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CDH23
Cadherin-23

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated w ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000224721
  • ENSP00000224721
  • ENSG00000107736
  • ENST00000398788
  • ENSP00000381768
  • ENST00000461841
  • ENSP00000473454
  • ENST00000619887
  • ENSP00000478374

Symbol
  • KIAA1774
  • KIAA1812
  • PITA5
  • USH1D
  • CDHR23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
transcription factor
0.76
cellular component
0.69
phenotype
0.67
disease
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.44   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.44   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
2
3
89.1
lymphocyte count
3
1
3
84.2
myeloid white cell count
3
1
3
83.9
neutrophil count
2
1
2
76
progranulin measurement
1
1
1
67.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
89.1
lymphocyte count
3
84.2
myeloid white cell count
3
83.9
neutrophil count
2
76
progranulin measurement
1
67.2
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cadherin related 23
709433
Mouse
MGI:1890219
22295
Dog
cadherin related 23
VGNC:50871
100684999
Cow
cadherin related 23
784716
Pig
cadherin related 23
100157198
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cadherin related 23
Mouse
Dog
cadherin related 23
Cow
cadherin related 23
Pig
cadherin related 23
Protein Structure (6 Structures, 11 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (107)
1 – 10 of 107
CD160
Tbio
Novelty: 0.01511748
p_int: 0.994915452
p_ni: 0.005043698
p_wrong: 0.000040851
Data Source: BioPlex
USH1C
Tbio
Novelty: 0.01066917
Score: 0.999
Data Source: STRINGDB
MYO7A
Tbio
Novelty: 0.00314435
Score: 0.968
Data Source: STRINGDB
PCDH15
Tbio
Novelty: 0.0097699
Score: 0.882
Data Source: STRINGDB
USH1G
Tbio
Novelty: 0.02912203
Score: 0.882
Data Source: STRINGDB
MYO15A
Tbio
Novelty: 0.0148787
Score: 0.841
Data Source: STRINGDB
WHRN
Tbio
Novelty: 0.01886351
Score: 0.839
Data Source: STRINGDB
USH2A
Tbio
Novelty: 0.00223387
Score: 0.815
Data Source: STRINGDB
TMC1
Tbio
Family: IC
Novelty: 0.00609628
Score: 0.815
Data Source: STRINGDB
ADGRV1
Tbio
Family: GPCR
Novelty: 0.01398129
Score: 0.807
Data Source: STRINGDB
Publication Statistics
PubMed Score  188.44

PubMed score by year
PubTator Score  84.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: