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Tchem
PORCN
Protein-serine O-palmitoleoyltransferase porcupine

Protein Summary
Description
Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors. This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326194
  • ENSP00000322304
  • ENSG00000102312
  • ENST00000355961
  • ENSP00000348233
  • ENST00000359882
  • ENSP00000352946
  • ENST00000361988
  • ENSP00000354978
  • ENST00000367574
  • ENSP00000356546
  • ENST00000537758
  • ENSP00000446401

Symbol
  • MG61
  • PORC
  • PPN
  • PPN
  • DHOF
  • FODH
  • MG61
  • PORC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
kinase perturbation
0.76
cellular component
0.7
PubMedID
0.62
small molecule perturbation
0.62


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.23   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.23   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 60
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1890212
53627
Rat
RGD:1564947
317368
Dog
porcupine O-acyltransferase
VGNC:44821
480903
Horse
porcupine O-acyltransferase
VGNC:21703
100051598
Cow
porcupine O-acyltransferase
VGNC:33170
540373
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
porcupine O-acyltransferase
Horse
porcupine O-acyltransferase
Cow
porcupine O-acyltransferase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H237-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (25)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
Signaling by WNT in cancer
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Signal Transduction
Signaling by WNT
Signaling by WNT in cancer
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (76)
1 – 10 of 76
WNT1
Tbio
Novelty:  0.00124301
Score:  0.994
Data Source:  STRINGDB
WNT3A
Tchem
Novelty:  0.00119275
Score:  0.976
Data Source:  STRINGDB
WNT6
Tbio
Novelty:  0.00842841
Score:  0.974
Data Source:  STRINGDB
WNT7B
Tbio
Novelty:  0.00684526
Score:  0.971
Data Source:  STRINGDB
WNT4
Tbio
Novelty:  0.00276803
Score:  0.97
Data Source:  STRINGDB
WNT5B
Tbio
Novelty:  0.00919779
Score:  0.97
Data Source:  STRINGDB
WNT5A
Tbio
Novelty:  0.00125563
Score:  0.965
Data Source:  STRINGDB
WNT9A
Tbio
Novelty:  0.01259196
Score:  0.963
Data Source:  STRINGDB
WNT9B
Tbio
Novelty:  0.01146843
Score:  0.963
Data Source:  STRINGDB
WNT2B
Tbio
Novelty:  0.00783711
Score:  0.961
Data Source:  STRINGDB
Publication Statistics
PubMed Score  132.23

PubMed score by year
PubTator Score  116.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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