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Tclin
S1PR5
Sphingosine 1-phosphate receptor 5

Protein Summary
Description
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333430
  • ENSP00000328472
  • ENSG00000180739
  • ENST00000439028
  • ENSP00000416915

Symbol
  • EDG8
  • EDG8
  • S1P5
  • Edg-8
  • SPPR-1
  • SPPR-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
histone modification site profile
0.59
protein domain
0.58
tissue sample
0.58
gene perturbation
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.1   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.1   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 161
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
3.8
low density lipoprotein cholesterol measurement
1
1
1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
3.8
low density lipoprotein cholesterol measurement
1
2.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sphingosine-1-phosphate receptor 5
712977
Mouse
MGI:2150641
94226
Rat
RGD:620566
60399
Dog
sphingosine-1-phosphate receptor 5
VGNC:45838
610828
Cow
sphingosine-1-phosphate receptor 5
VGNC:34256
517533
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sphingosine-1-phosphate receptor 5
Mouse
Rat
Dog
sphingosine-1-phosphate receptor 5
Cow
sphingosine-1-phosphate receptor 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H228-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Lysosphingolipid and LPA receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Lysosphingolipid and LPA receptors
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (251)
1 – 10 of 251
GPR21
Tdark
Family: GPCR
Novelty: 0.90865557
p_int: 0.999774091
p_ni: 0.000067144
p_wrong: 0.000158765
Data Source: BioPlex
VNN2
Tbio
Novelty: 0.02286648
p_int: 0.999520613
p_ni: 0.000094454
p_wrong: 0.000384933
Score: 0.175
Data Source: BioPlex,STRINGDB
SLC39A4
Tbio
Family: Transporter
Novelty: 0.00742159
p_int: 0.999403233
p_ni: 0.000027462
p_wrong: 0.000569305
Data Source: BioPlex
UPK1A
Tbio
Novelty: 0.01748122
p_int: 0.981427603
p_ni: 0.000082504
p_wrong: 0.018489893
Data Source: BioPlex
LPAR5
Tchem
Family: GPCR
Novelty: 0.01883439
Score: 0.945
Data Source: STRINGDB
GNA12
Tbio
Novelty: 0.06310884
Score: 0.939
Data Source: STRINGDB
GNAO1
Tbio
Novelty: 0.00315097
Score: 0.937
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.935
Data Source: STRINGDB
CCR7
Tbio
Family: GPCR
Novelty: 0.00084453
Score: 0.933
Data Source: STRINGDB
CX3CR1
Tchem
Family: GPCR
Novelty: 0.00114874
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  76.10

PubMed score by year
PubTator Score  34.89

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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