ABCG8
ATP-binding cassette sub-family G member 8
You are using an outdated browser. Please upgrade your browser to improve your experience.
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.98 | ||
trait | 0.75 | ||
biological term | 0.68 | ||
cell line | 0.67 | ||
disease | 0.67 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | ABC transporter disorders | ||||
Reactome | ABC transporters in lipid homeostasis | ||||
Reactome | ABC-family proteins mediated transport | ||||
Reactome | Defective ABCG5 causes sitosterolemia | ||||
Reactome | Defective ABCG8 causes gallbladder disease 4 and sitosterolemia | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ABC transporter disorders | ||||
ABC transporters in lipid homeostasis | ||||
ABC-family proteins mediated transport | ||||
Defective ABCG5 causes sitosterolemia | ||||
Defective ABCG8 causes gallbladder disease 4 and sitosterolemia | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 12 | 18 | 25 | 3.5 | 99.8 | ||||
total cholesterol measurement | 9 | 18 | 21 | 3.6 | 99.2 | ||||
apolipoprotein B measurement | 2 | 8 | 8 | 99.2 | |||||
4 | 2 | 0 | 1.8 | 96.1 | |||||
phytosterol measurement | 1 | 2 | 0 | 13 | 92.9 | ||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 25 | 3.5 | 99.8 | ||||
total cholesterol measurement | 21 | 3.6 | 99.2 | ||||
apolipoprotein B measurement | 8 | 99.2 | |||||
0 | 1.8 | 96.1 | |||||
phytosterol measurement | 0 | 13 | 92.9 | ||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ATP binding cassette subfamily G member 8 | VGNC:4 | 470363 | |||||
Macaque | ATP binding cassette subfamily G member 8 | 713676 | ||||||
Mouse | MGI:1914720 | 67470 | ||||||
Rat | RGD:620300 | 155192 | ||||||
Dog | ATP binding cassette subfamily G member 8 | VGNC:37455 | 474571 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | ATP binding cassette subfamily G member 8 | |||||
Macaque | ATP binding cassette subfamily G member 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ATP binding cassette subfamily G member 8 | |||||
PMID | Year | Title |
---|