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Tbio
ABCG8
ATP-binding cassette sub-family G member 8

Protein Summary
Description
ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356). The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272286
  • ENSP00000272286
  • ENSG00000143921
  • ENST00000645013
  • ENSP00000496450

Symbol
  • GBD4
  • STSL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
trait
0.75
biological term
0.68
cell line
0.67
disease
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.26   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.26   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
11
10
17
3.5
99.6
gallstones
4
2
0
1.8
99.6
total cholesterol measurement
8
10
13
3.6
99
phytosterol measurement
1
2
0
13
98.6
6
4
4
1.1
87.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
17
3.5
99.6
gallstones
0
1.8
99.6
total cholesterol measurement
13
3.6
99
phytosterol measurement
0
13
98.6
4
1.1
87.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily G member 8
VGNC:4
470363
Macaque
ATP binding cassette subfamily G member 8
713676
Mouse
MGI:1914720
67470
Rat
RGD:620300
155192
Dog
ATP binding cassette subfamily G member 8
VGNC:37455
474571
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily G member 8
Macaque
ATP binding cassette subfamily G member 8
Mouse
Rat
Dog
ATP binding cassette subfamily G member 8
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H221-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Defective ABCG5 causes sitosterolemia
Reactome
Defective ABCG8 causes gallbladder disease 4 and sitosterolemia
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Defective ABCG5 causes sitosterolemia
Defective ABCG8 causes gallbladder disease 4 and sitosterolemia
Gene Ontology Terms (20)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (103)
1 – 10 of 103
TSPAN3
Tbio
Novelty: 0.06362133
p_int: 0.9870562
p_ni: 0.012943793
p_wrong: 7e-9
Score: 0.561
Data Source: BioPlex,STRINGDB
PTPRD
Tbio
Family: Enzyme
Novelty: 0.01059407
p_int: 0.952630415
p_ni: 0.047356817
p_wrong: 0.000012768
Score: 0.175
Data Source: BioPlex,STRINGDB
CD320
Tbio
Novelty: 0.01978884
p_int: 0.875302535
p_ni: 0.124694465
p_wrong: 0.000002999
Score: 0.561
Data Source: BioPlex,STRINGDB
NOTCH3
Tchem
Novelty: 0.000953
p_int: 0.767712072
p_ni: 0.228493585
p_wrong: 0.003794343
Score: 0.795
Data Source: BioPlex,STRINGDB
TMEM184B
Tdark
Novelty: 0.35340207
p_int: 0.757074799
p_ni: 0.121483708
p_wrong: 0.121441493
Score: 0.248
Data Source: BioPlex,STRINGDB
ABCG5
Tbio
Family: Transporter
Novelty: 0.00340812
Score: 0.992
Data Source: Reactome,STRINGDB
ABCD4
Tbio
Family: Transporter
Novelty: 0.04096359
Score: 0.944
Data Source: STRINGDB
ABCB6
Tbio
Family: Transporter
Novelty: 0.00552057
Score: 0.927
Data Source: STRINGDB
ABCA2
Tbio
Family: Transporter
Novelty: 0.02208136
Score: 0.922
Data Source: STRINGDB
ATP1A4
Tclin
Family: Transporter
Novelty: 0.01011201
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score  209.26

PubMed score by year
PubTator Score  125.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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