You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ABCG8
ATP-binding cassette sub-family G member 8

Protein Summary
Description
ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356). The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272286
  • ENSP00000272286
  • ENSG00000143921
  • ENST00000645013
  • ENSP00000496450

Symbol
  • GBD4
  • STSL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
trait
0.75
biological term
0.68
cell line
0.67
disease
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.32   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.32   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
TSPAN3
Tbio
Novelty:  0.06362133
p_int:  0.9870562
p_ni:  0.012943793
p_wrong:  7e-9
Score:  0.561
Data Source:  BioPlex,STRINGDB
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.952630415
p_ni:  0.047356817
p_wrong:  0.000012768
Score:  0.175
Data Source:  BioPlex,STRINGDB
CD320
Tbio
Novelty:  0.01978884
p_int:  0.875302535
p_ni:  0.124694465
p_wrong:  0.000002999
Score:  0.561
Data Source:  BioPlex,STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
p_int:  0.767712072
p_ni:  0.228493585
p_wrong:  0.003794343
Score:  0.795
Data Source:  BioPlex,STRINGDB
TMEM184B
Tbio
Novelty:  0.35340207
p_int:  0.757074799
p_ni:  0.121483708
p_wrong:  0.121441493
Score:  0.248
Data Source:  BioPlex,STRINGDB
ABCG5
Tbio
Family:  Transporter
Novelty:  0.00340812
Score:  0.992
Data Source:  Reactome,STRINGDB
ABCD4
Tbio
Family:  Transporter
Novelty:  0.04096359
Score:  0.944
Data Source:  STRINGDB
ABCB6
Tbio
Family:  Transporter
Novelty:  0.00552057
Score:  0.927
Data Source:  STRINGDB
ABCA2
Tbio
Family:  Transporter
Novelty:  0.02208136
Score:  0.922
Data Source:  STRINGDB
ATP1A4
Tclin
Family:  Transporter
Novelty:  0.01011201
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Defective ABCG5 causes sitosterolemia
Reactome
Defective ABCG8 causes gallbladder disease 4 and sitosterolemia
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Defective ABCG5 causes sitosterolemia
Defective ABCG8 causes gallbladder disease 4 and sitosterolemia
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (52)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
44
20
57
3.5
99.8
total cholesterol measurement
23
20
35
3.6
99.4
4
2
0
1.8
99
phytosterol measurement
1
2
0
13
97.8
lipid measurement
12
4
11
6
97.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
57
3.5
99.8
total cholesterol measurement
35
3.6
99.4
0
1.8
99
phytosterol measurement
0
13
97.8
lipid measurement
11
6
97.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily G member 8
VGNC:4
470363
Macaque
ATP binding cassette subfamily G member 8
713676
Mouse
MGI:1914720
67470
Rat
RGD:620300
155192
Dog
ATP binding cassette subfamily G member 8
VGNC:37455
474571
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily G member 8
Macaque
ATP binding cassette subfamily G member 8
Mouse
Rat
Dog
ATP binding cassette subfamily G member 8
Publication Statistics
PubMed Score 244.32
PubMed score by year
PubTator Score 125.67
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title