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Tbio
CDT1
DNA replication factor Cdt1

Protein Summary
Description
Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301019
  • ENSP00000301019
  • ENSG00000167513

Symbol
  • DUP
  • RIS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
disease perturbation
0.9
transcription factor binding site profile
0.83
histone modification site profile
0.77
hub protein
0.75


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.45   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.45   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromatin licensing and DNA replication factor 1
VGNC:5723
468072
Macaque
chromatin licensing and DNA replication factor 1
711530
Mouse
MGI:1914427
67177
Rat
RGD:1309211
292071
Dog
chromatin licensing and DNA replication factor 1
VGNC:39083
479616
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromatin licensing and DNA replication factor 1
Macaque
chromatin licensing and DNA replication factor 1
Mouse
Rat
Dog
chromatin licensing and DNA replication factor 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H211-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Activation of the pre-replicative complex (R-HSA-68962)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the pre-replicative complex
Reactome
CDT1 association with the CDC6:ORC:origin complex
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Activation of the pre-replicative complex
Assembly of the pre-replicative complex
CDT1 association with the CDC6:ORC:origin complex
Cell Cycle
Cell Cycle, Mitotic
Gene Ontology Terms (33)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (293)
1 – 10 of 293
GMNN
Tbio
Novelty: 0.00436572
p_int: 0.999999982
p_ni: 1.6e-8
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CCNA2
Tchem
Novelty: 0.00049887
p_int: 0.999999853
p_ni: 1.46e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
CKS1B
Tbio
Family: Enzyme
Novelty: 0.00766779
p_int: 0.999999671
p_ni: 3.29e-7
Score: 0.933
Data Source: BioPlex,STRINGDB
CDK3
Tchem
Family: Kinase
Novelty: 0.03380289
p_int: 0.999995338
p_ni: 0.000004662
Score: 0.749
Data Source: BioPlex,STRINGDB
CKS2
Tbio
Family: Enzyme
Novelty: 0.02482411
p_int: 0.999885365
p_ni: 0.000114596
p_wrong: 3.9e-8
Score: 0.911
Data Source: BioPlex,STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
p_int: 0.998630143
p_ni: 0.001320007
p_wrong: 0.00004985
Score: 0.99
Data Source: BioPlex,STRINGDB
MCM4
Tbio
Novelty: 0.00604311
Score: 0.999
Data Source: STRINGDB
MCM3
Tbio
Novelty: 0.00593382
Score: 0.999
Data Source: STRINGDB
MCM7
Tbio
Novelty: 0.0017984
Score: 0.999
Data Source: STRINGDB
MCM6
Tbio
Novelty: 0.00675724
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  252.45

PubMed score by year
PubTator Score  170.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer