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Tdark
TSPAN10
Tetraspanin-10

Protein Summary
Description
Regulates maturation of the transmembrane metalloprotease ADAM10.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328585
  • ENSP00000331620
  • ENSG00000182612

Symbol
  • OCSP
  • OCSP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.59
cell line
0.58
protein domain
0.58
tissue sample
0.53
tissue
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.42   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.42   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.999674336
p_ni:  0.000325659
p_wrong:  6e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
HSD17B13
Tbio
Family:  Enzyme
Novelty:  0.0328105
p_int:  0.997588923
p_ni:  0.001604625
p_wrong:  0.000806452
Score:  0.68
Data Source:  BioPlex,STRINGDB
PNLDC1
Tbio
Family:  Enzyme
Novelty:  0.16308361
p_int:  0.95879372
p_ni:  0.040986357
p_wrong:  0.000219923
Score:  0.199
Data Source:  BioPlex,STRINGDB
CD9
Tbio
Novelty:  0.00095308
Score:  0.685
Data Source:  STRINGDB
CD81
Tchem
Novelty:  0.00111328
Score:  0.663
Data Source:  STRINGDB
IFNW1
Tbio
Novelty:  0.1308421
Score:  0.622
Data Source:  STRINGDB
ADAM10
Tchem
Family:  Enzyme
Novelty:  0.00160129
Score:  0.596
Data Source:  STRINGDB
NANS
Tbio
Family:  Enzyme
Novelty:  0.00718044
Score:  0.568
Data Source:  STRINGDB
TFPI
Tchem
Novelty:  0.00060355
Score:  0.567
Data Source:  STRINGDB
TNFRSF13B
Tbio
Novelty:  0.00338954
Score:  0.551
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
3
3
0
1.1
96.9
Myopia
3
3
0
1.2
86.3
refractive error measurement
2
3
2
5.9
84.6
serum gamma-glutamyl transferase measurement
1
3
3
79.8
ganglion cell inner plexiform layer thickness measurement
1
1
1
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
96.9
Myopia
0
1.2
86.3
refractive error measurement
2
5.9
84.6
serum gamma-glutamyl transferase measurement
3
79.8
ganglion cell inner plexiform layer thickness measurement
1
79.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tetraspanin 10
714103
Mouse
MGI:2384781
208634
Chicken
tetraspanin 10
CGNC:3343
417455
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tetraspanin 10
Mouse
Chicken
tetraspanin 10
Publication Statistics
PubMed Score 6.42
PubMed score by year
PubTator Score 4.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title