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Tbio
OPN3
Opsin-3

Protein Summary
Description
May play a role in encephalic photoreception. Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366554
  • ENSP00000355512
  • ENSG00000054277

Symbol
  • ECPN
  • ECPN
  • PPP1R116
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
PubMedID
0.78
transcription factor perturbation
0.68
transcription factor binding site profile
0.64
histone modification site profile
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.58   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.58   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
72.1
self reported educational attainment
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
72.1
self reported educational attainment
1
62.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
opsin 3
VGNC:6924
457854
Macaque
opsin 3
707436
Mouse
MGI:1338022
13603
Rat
RGD:1594385
498289
Dog
opsin 3
VGNC:44130
102155438
Species
Name
OMA
EggNOG
Inparanoid
Chimp
opsin 3
Macaque
opsin 3
Mouse
Rat
Dog
opsin 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H1Y3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Opsins
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Opsins
Protein-Protein Interactions (58)
1 – 10 of 58
EIF2B3
Tbio
Novelty:  0.04963646
p_int:  0.987707536
p_ni:  0.012292464
Score:  0.787
Data Source:  BioPlex,STRINGDB
EIF2B2
Tbio
Novelty:  0.03253919
p_int:  0.978287073
p_ni:  0.021712927
Score:  0.816
Data Source:  BioPlex,STRINGDB
EIF2B4
Tbio
Novelty:  0.05080792
p_int:  0.972365549
p_ni:  0.027634451
Score:  0.207
Data Source:  BioPlex,STRINGDB
EIF2B5
Tbio
Novelty:  0.0102209
p_int:  0.823399672
p_ni:  0.176600328
Score:  0.702
Data Source:  BioPlex,STRINGDB
GNAT2
Tbio
Novelty:  0.01683655
Score:  0.935
Data Source:  STRINGDB
RGR
Tbio
Family:  GPCR
Novelty:  0.03133861
Score:  0.927
Data Source:  STRINGDB
OPN5
Tbio
Family:  GPCR
Novelty:  0.02890415
Score:  0.925
Data Source:  STRINGDB
GNAT1
Tbio
Novelty:  0.03042002
Score:  0.925
Data Source:  STRINGDB
GNB5
Tbio
Novelty:  0.0067714
Score:  0.924
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.916
Data Source:  STRINGDB
Publication Statistics
PubMed Score  65.58

PubMed score by year
PubTator Score  12

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer