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Tbio
ATG5
Autophagy protein 5

Protein Summary
Description
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. May play an important role in the apopto ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343245
  • ENSP00000343313
  • ENSG00000057663
  • ENST00000369076
  • ENSP00000358072
  • ENST00000635758
  • ENSP00000490493

Symbol
  • APG5L
  • ASP
  • ASP
  • APG5
  • APG5L
  • hAPG5
  • SCAR25
  • APG5-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
biological process
0.99
kinase perturbation
0.99
transcription factor perturbation
0.94
transcription factor binding site profile
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1224.76   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 884   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1224.76   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 884   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
5
0
1.2
92
4
4
1
1.1
83.8
balding measurement
1
1
1
82.8
eosinophil count
2
2
2
78.6
1
1
0
1.2
75.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
92
1
1.1
83.8
balding measurement
1
82.8
eosinophil count
2
78.6
0
1.2
75.8
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autophagy related 5
VGNC:2644
462905
Macaque
autophagy related 5
696874
Mouse
MGI:1277186
11793
Rat
RGD:1359580
365601
Dog
autophagy related 5
VGNC:38226
610868
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autophagy related 5
Macaque
autophagy related 5
Mouse
Rat
Dog
autophagy related 5
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H1Y0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Gene Ontology Terms (42)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (247)
1 – 10 of 247
ATG3
Tbio
Novelty: 0.00541077
p_int: 0.99999999
p_ni: 7e-9
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
RAB33B
Tbio
Family: Enzyme
Novelty: 0.06381712
p_int: 0.999999833
p_ni: 1.67e-7
p_wrong: 1e-9
Score: 0.512
Data Source: BioPlex,STRINGDB
CCDC12
Tdark
Novelty: 0.52297992
p_int: 0.999999802
p_ni: 1.98e-7
Score: 0.534
Data Source: BioPlex,STRINGDB
WIPI2
Tbio
Novelty: 0.02685992
p_int: 0.999991799
p_ni: 0.000003865
p_wrong: 0.000004336
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
IKBIP
Tbio
Family: Enzyme
Novelty: 0.18707639
p_int: 0.999973371
p_ni: 0.000026623
p_wrong: 7e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
SYCE1
Tbio
Novelty: 0.05038876
p_int: 0.998756131
p_ni: 0.001220201
p_wrong: 0.000023668
Data Source: BioPlex
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.988746027
p_ni: 0.011239493
p_wrong: 0.00001448
Data Source: BioPlex
ATG16L1
Tbio
Novelty: 0.0031765
Score: 0.999
Data Source: Reactome,STRINGDB
ATG12
Tbio
Novelty: 0.00304298
Score: 0.999
Data Source: Reactome,STRINGDB
ATG7
Tbio
Novelty: 0.00120728
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  1224.76

PubMed score by year
PubTator Score  513.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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