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Tbio
SLC6A17
Sodium-dependent neutral amino acid transporter SLC6A17

Protein Summary
Description
Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity). The protein encoded by this gene is a member of the SLC6 family of transporters, which are responsible for the presynaptic uptake of most neurotransmitters. The encoded vesicular transporter is selective for proline, glycine, leucine and alanine. In mouse, the strongest expression of this gene was in cortical and hippocampal tissues where expression increased during embryonic brain development and peaked postnatally. Defects in this gene cause a form of autosomal recessive intellectual disability. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331565
  • ENSP00000330199
  • ENSG00000197106

Symbol
  • NTT4
  • NTT4
  • MRT48
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.8
kinase perturbation
0.66
tissue sample
0.65
molecular function
0.63
cellular component
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.01   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.01   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (42)
1 – 10 of 42
UBL4B
Tdark
Novelty:  0.56877836
Score:  0.904
Data Source:  STRINGDB
TEX15
Tbio
Novelty:  0.08059572
Score:  0.75
Data Source:  STRINGDB
ALX3
Tbio
Family:  TF
Novelty:  0.02711914
Score:  0.723
Data Source:  STRINGDB
STRIP1
Tbio
Novelty:  0.13320106
Score:  0.721
Data Source:  STRINGDB
SLC29A3
Tbio
Family:  Transporter
Novelty:  0.01133239
Score:  0.714
Data Source:  STRINGDB
TMEM151B
Tdark
Novelty:  2.15276454
Score:  0.671
Data Source:  STRINGDB
SLC20A1
Tbio
Family:  Transporter
Novelty:  0.01123373
Score:  0.645
Data Source:  STRINGDB
SLC22A16
Tbio
Family:  Transporter
Novelty:  0.03379851
Score:  0.625
Data Source:  STRINGDB
SLC47A1
Tchem
Family:  Transporter
Novelty:  0.00535064
Score:  0.624
Data Source:  STRINGDB
SLC17A3
Tbio
Family:  Transporter
Novelty:  0.04671795
Score:  0.618
Data Source:  STRINGDB
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
71.9
mathematical ability
3
1
3
70
cognitive function measurement
1
2
2
59.4
red blood cell density measurement
1
1
1
50.6
age at first sexual intercourse measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
71.9
mathematical ability
3
70
cognitive function measurement
2
59.4
red blood cell density measurement
1
50.6
age at first sexual intercourse measurement
1
38.8
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 17
VGNC:8115
457123
Macaque
solute carrier family 6 member 17
701162
Mouse
MGI:2442535
229706
Rat
RGD:1587185
613226
Dog
solute carrier family 6 member 17
VGNC:46459
490115
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 17
Macaque
solute carrier family 6 member 17
Mouse
Rat
Dog
solute carrier family 6 member 17
Publication Statistics
PubMed Score 12.01
PubMed score by year
PubTator Score 2.00
PubTator score by year