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Tchem
MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

Protein Summary
Description
Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375985
  • ENSP00000365152
  • ENSG00000101306
  • ENST00000375994
  • ENSP00000365162

Symbol
  • KMLC
  • MLCK
  • MLCK2
  • skMLCK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.85
hub protein
0.75
interacting protein
0.72
cell type or tissue
0.69


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.29   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.29   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL2171125
chemical structure image
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
putamen volume
1
1
0
8
82.3
caudate nucleus volume
1
1
0
7.1
75.8
platelet crit
2
2
2
71.7
platelet count
2
2
2
62.3
pallidum volume
1
1
0
5.7
46.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
putamen volume
0
8
82.3
caudate nucleus volume
0
7.1
75.8
platelet crit
2
71.7
platelet count
2
62.3
pallidum volume
0
5.7
46.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin light chain kinase 2
VGNC:6195
742591
Macaque
myosin light chain kinase 2
712830
Mouse
MGI:2139434
228785
Rat
RGD:620934
117558
Dog
myosin light chain kinase 2
VGNC:43550
477187
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin light chain kinase 2
Macaque
myosin light chain kinase 2
Mouse
Rat
Dog
myosin light chain kinase 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H1R3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Platelet activation
KEGG
Focal adhesion
KEGG
Oxytocin signaling pathway
KEGG
Gastric acid secretion
KEGG
Regulation of actin cytoskeleton
Name
Explore in Pharos
Explore in Source
Platelet activation
Focal adhesion
Oxytocin signaling pathway
Gastric acid secretion
Regulation of actin cytoskeleton
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (86)
1 – 10 of 86
RPS6KA4
Tchem
Family: Kinase
Novelty: 0.05213255
p_int: 0.999999632
p_ni: 3.68e-7
Score: 0.537
Data Source: BioPlex,STRINGDB
TMEM260
Tdark
Novelty: 0.31409768
p_int: 0.999835411
p_ni: 0.000164578
p_wrong: 1e-8
Score: 0.345
Data Source: BioPlex,STRINGDB
GSTT1
Tbio
Family: Enzyme
p_int: 0.999606741
p_ni: 0.000002919
p_wrong: 0.00039034
Data Source: BioPlex
FBXO11
Tbio
Novelty: 0.02762674
p_int: 0.99866972
p_ni: 0.001330279
Score: 0.177
Data Source: BioPlex,STRINGDB
SMDT1
Tbio
Novelty: 0.02448475
p_int: 0.868192546
p_ni: 0.131806089
p_wrong: 0.000001366
Score: 0.313
Data Source: BioPlex,STRINGDB
C12orf65
Tbio
Family: Enzyme
Novelty: 0.06088466
p_int: 0.865194938
p_ni: 0.134804531
p_wrong: 5.31e-7
Score: 0.689
Data Source: BioPlex,STRINGDB
MYL12A
Tbio
Novelty: 0.00944255
Score: 0.973
Data Source: STRINGDB
MYL9
Tbio
Novelty: 0.00309239
Score: 0.968
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.952
Data Source: STRINGDB
MYL12B
Tbio
Novelty: 0.00999083
Score: 0.883
Data Source: STRINGDB
Publication Statistics
PubMed Score  120.29

PubMed score by year
PubTator Score  17.14

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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