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Tbio
DUSP15
Dual specificity protein phosphatase 15

Protein Summary
Description
May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (PubMed:22792334). Isoform 3: May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity). The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278979
  • ENSP00000278979
  • ENSG00000149599
  • ENST00000339738
  • ENSP00000341658
  • ENST00000375966
  • ENSP00000365133
  • ENST00000398083
  • ENSP00000381157
  • ENST00000398084
  • ENSP00000381158
  • ENST00000486996
  • ENSP00000419818

Symbol
  • C20orf57
  • VHY
  • VHY
  • C20orf57
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
gene perturbation
0.68
cell type or tissue
0.65
transcription factor
0.62
kinase perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.04   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.04   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
93
platelet count
2
2
2
85.7
mean reticulocyte volume
1
1
1
81.7
mosaic loss of chromosome Y measurement
1
1
1
68.6
putamen volume
1
1
0
8
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
93
platelet count
2
85.7
mean reticulocyte volume
1
81.7
mosaic loss of chromosome Y measurement
1
68.6
putamen volume
0
8
64.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 15
VGNC:13847
470021
Macaque
dual specificity phosphatase 15
100431027
Mouse
MGI:1934928
252864
Rat
RGD:1305990
362238
Cow
dual specificity phosphatase 15
VGNC:50028
618412
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 15
Macaque
dual specificity phosphatase 15
Mouse
Rat
Cow
dual specificity phosphatase 15
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H1R2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (23)
1 – 10 of 23
DUSP23
Tbio
Family:  Enzyme
Novelty:  0.06522366
Score:  0.708
Data Source:  STRINGDB
XKR7
Tdark
Novelty:  4.81867425
Score:  0.645
Data Source:  STRINGDB
FOXS1
Tbio
Family:  TF
Novelty:  0.17661517
Score:  0.581
Data Source:  STRINGDB
PIMREG
Tbio
Novelty:  0.02575266
Score:  0.569
Data Source:  STRINGDB
FAM222A
Tdark
Novelty:  0.41466126
Score:  0.568
Data Source:  STRINGDB
CCM2L
Tdark
Novelty:  0.78133775
Score:  0.566
Data Source:  STRINGDB
ECSCR
Tbio
Novelty:  0.11603718
Score:  0.562
Data Source:  STRINGDB
PPP1R32
Tdark
Family:  Enzyme
Novelty:  0.38056479
Score:  0.556
Data Source:  STRINGDB
C7orf57
Tdark
Novelty:  2.76091387
Score:  0.546
Data Source:  STRINGDB
RASL11A
Tdark
Family:  Enzyme
Novelty:  0.32222053
Score:  0.538
Data Source:  STRINGDB
Publication Statistics
PubMed Score  15.04

PubMed score by year
PubTator Score  6.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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