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Tbio
OSBPL2
Oxysterol-binding protein-related protein 2

Protein Summary
Description
Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed:11279184). Binds 25-hydroxycholesterol (PubMed:17428193). This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313733
  • ENSP00000316649
  • ENSG00000130703
  • ENST00000358053
  • ENSP00000350755
  • ENST00000643412
  • ENSP00000494549
  • ENST00000643981
  • ENSP00000495379

Symbol
  • KIAA0772
  • ORP2
  • ORP2
  • ORP-2
  • DFNA67
  • DNFA67
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.87
virus perturbation
0.72
tissue sample
0.68
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.76   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.76   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
4
0
1.2
92.6
1
1
0
1.1
77.9
reticulocyte measurement
2
1
2
71.2
alkaline phosphatase measurement
2
2
1
6
69.6
glomerular filtration rate
2
2
2
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
92.6
0
1.1
77.9
reticulocyte measurement
2
71.2
alkaline phosphatase measurement
1
6
69.6
glomerular filtration rate
2
69.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
oxysterol binding protein like 2
VGNC:6217
737641
Macaque
oxysterol binding protein like 2
699811
Mouse
MGI:2442832
228983
Rat
RGD:1311312
296461
Dog
oxysterol binding protein like 2
VGNC:44154
477283
Species
Name
OMA
EggNOG
Inparanoid
Chimp
oxysterol binding protein like 2
Macaque
oxysterol binding protein like 2
Mouse
Rat
Dog
oxysterol binding protein like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H1P3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Synthesis of bile acids and bile salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Synthesis of bile acids and bile salts
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (24)
1 – 10 of 24
VAPA
Tbio
Novelty:  0.00169209
p_int:  1
Score:  0.813
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  1
Score:  0.569
Data Source:  BioPlex,STRINGDB
APBB2
Tbio
Novelty:  0.06546724
p_int:  0.99987232
p_ni:  0.000127671
p_wrong:  8e-9
Score:  0.198
Data Source:  BioPlex,STRINGDB
ZFPL1
Tbio
Novelty:  0.1829181
p_int:  0.999737052
p_ni:  0.000262947
Score:  0.547
Data Source:  BioPlex,STRINGDB
BIRC6
Tbio
Novelty:  0.01187953
p_int:  0.791696849
p_ni:  0.208303151
Score:  0.189
Data Source:  BioPlex,STRINGDB
STXBP5L
Tbio
Novelty:  0.13081646
Score:  0.698
Data Source:  STRINGDB
ADRM1
Tbio
Novelty:  0.01545209
Score:  0.647
Data Source:  STRINGDB
ABHD3
Tbio
Family:  Enzyme
Novelty:  0.24877871
Score:  0.628
Data Source:  STRINGDB
RBBP8NL
Tdark
Novelty:  3.33075673
Score:  0.587
Data Source:  STRINGDB
STXBP5
Tbio
Novelty:  0.01899802
Score:  0.568
Data Source:  STRINGDB
Publication Statistics
PubMed Score  31.76

PubMed score by year
PubTator Score  16.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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