SLC35B3
Adenosine 3'-phospho 5'-phosphosulfate transporter 2
Protein Summary
Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon. This gene is a member of the solute carrier family. The encoded protein is involved in the transport of 3-prime phosphoadenosine 5-prime phosphosulfate (PAPS) from the nucleus or the cytosol to the Golgi lumen. This gene has been reported to be expressed preferentially in the human colon tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
- ENST00000379660
- ENSP00000368981
- ENSG00000124786
- ENST00000644923
- ENSP00000496368
- ENST00000648867
- ENSP00000497645
- C6orf196
- PAPST2
- CGI-19
- PAPST2
- C6orf196
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.99 | ||
kinase perturbation | 0.81 | ||
histone modification site profile | 0.74 | ||
tissue sample | 0.72 | ||
biological process | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.33 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 9 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.33 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 9 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0