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Tbio
DEFB127
Beta-defensin 127

Protein Summary
Description
Has antibacterial activity. Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382388
  • ENSP00000371825
  • ENSG00000088782

Symbol
  • C20orf73
  • DEFB27
  • DEF-27
  • DEFB27
  • hBD-27
  • DEFB-27
  • C20orf73
  • bA530N10.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.45
cell line
0.44
cell type or tissue
0.41
virus perturbation
0.41
protein complex
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.93   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 6   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.93   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (45)
1 – 10 of 45
HTRA1
Tbio
Family: Enzyme
Novelty: 0.00171455
p_int: 0.999498869
p_ni: 0.000501109
p_wrong: 2.2e-8
Score: 0.157
Data Source: BioPlex,STRINGDB
ACTR10
Tbio
Novelty: 0.17285319
p_int: 0.999326072
p_ni: 0.000673928
Score: 0.691
Data Source: BioPlex,STRINGDB
DCTN6
Tdark
Novelty: 0.93301435
p_int: 0.999202096
p_ni: 0.000797904
Score: 0.811
Data Source: BioPlex,STRINGDB
DCTN5
Tdark
Novelty: 0.30523995
p_int: 0.997551362
p_ni: 0.002448637
Score: 0.819
Data Source: BioPlex,STRINGDB
SH3BGR
Tdark
Novelty: 0.26121618
p_int: 0.995441226
p_ni: 0.004558766
p_wrong: 8e-9
Score: 0.193
Data Source: BioPlex,STRINGDB
DCTN3
Tdark
Novelty: 0.2257271
p_int: 0.994601085
p_ni: 0.005398915
Score: 0.817
Data Source: BioPlex,STRINGDB
DCTN4
Tbio
Novelty: 0.12987013
p_int: 0.991836052
p_ni: 0.008163948
Score: 0.69
Data Source: BioPlex,STRINGDB
ACTBL2
Tbio
Novelty: 0.35273907
p_int: 0.969562561
p_ni: 0.030437439
Data Source: BioPlex
ACTR1B
Tbio
Novelty: 0.15424927
p_int: 0.967584036
p_ni: 0.032415964
Score: 0.812
Data Source: BioPlex,STRINGDB
ACTR1A
Tbio
Novelty: 0.1045483
p_int: 0.939015081
p_ni: 0.060984919
Score: 0.811
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  4.93

PubMed score by year
PubTator Score  2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer