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Tdark
DEFB129
Beta-defensin 129

Protein Summary
Description
Has antibacterial activity. Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246105
  • ENSP00000246105
  • ENSG00000125903

Symbol
  • C20orf87
  • DEFB29
  • DEFB29
  • hBD-29
  • DEFB-29
  • C20orf87
  • bA530N10.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.71
cell line
0.46
tissue sample
0.41
biological term
0.33
pathway
0.32


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (38)
1 – 10 of 38
DEFB125
Tdark
Novelty: 1.05263158
Score: 0.982
Data Source: STRINGDB
DEFB121
Tdark
Score: 0.973
Data Source: STRINGDB
DEFB113
Tdark
Novelty: 1.04347826
Score: 0.972
Data Source: STRINGDB
DEFB127
Tbio
Novelty: 0.21093001
Score: 0.97
Data Source: STRINGDB
DEFB126
Tbio
Novelty: 0.05895207
Score: 0.966
Data Source: STRINGDB
DEFB110
Tdark
Novelty: 1.55172414
Score: 0.964
Data Source: STRINGDB
DEFB128
Tbio
Novelty: 0.51083591
Score: 0.958
Data Source: STRINGDB
DEFB132
Tdark
Novelty: 0.4
Score: 0.958
Data Source: STRINGDB
DEFB123
Tdark
Novelty: 0.23476803
Score: 0.953
Data Source: STRINGDB
DEFB116
Tdark
Novelty: 5
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.94

PubMed score by year
PubTator Score  1.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer