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Tbio
WNT5B
Protein Wnt-5b

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310594
  • ENSP00000308887
  • ENSG00000111186
  • ENST00000397196
  • ENSP00000380379
  • ENST00000537031
  • ENSP00000439312
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.85
gene perturbation
0.71
pathway
0.67
transcription factor
0.57
biological process
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.42   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.42   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
74.1
bone density
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
74.1
bone density
1
26.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 5B
VGNC:10084
467191
Mouse
MGI:98959
22419
Rat
RGD:628850
282582
Dog
Wnt family member 5B
VGNC:48426
486756
Horse
Wnt family member 5B
VGNC:25047
100056017
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 5B
Mouse
Rat
Dog
Wnt family member 5B
Horse
Wnt family member 5B
Pathways (59)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
PCP/CE pathway
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
WNT ligand biogenesis and trafficking
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
PCP/CE pathway
Signal Transduction
Signaling by WNT
WNT ligand biogenesis and trafficking
Gene Ontology Terms (22)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (131)
1 – 10 of 131
WNT5A
Tbio
Novelty: 0.00125563
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.923
Data Source: BioPlex,STRINGDB
KLRG2
Tdark
Novelty: 1.19446694
p_int: 0.999659399
p_ni: 0.00000964
p_wrong: 0.000330961
Score: 0.189
Data Source: BioPlex,STRINGDB
FZD1
Tbio
Family: GPCR
Novelty: 0.01097201
Score: 0.98
Data Source: STRINGDB
FZD7
Tbio
Family: GPCR
Novelty: 0.00916448
Score: 0.974
Data Source: STRINGDB
FZD6
Tbio
Family: GPCR
Novelty: 0.01425136
Score: 0.972
Data Source: STRINGDB
RYK
Tbio
Family: Kinase
Novelty: 0.00910227
Score: 0.971
Data Source: STRINGDB
PORCN
Tchem
Family: Enzyme
Novelty: 0.00834643
Score: 0.97
Data Source: STRINGDB
DVL1
Tchem
Novelty: 0.00356876
Score: 0.97
Data Source: STRINGDB
WLS
Tbio
Novelty: 0.01459149
Score: 0.969
Data Source: STRINGDB
FZD3
Tbio
Family: GPCR
Novelty: 0.00964507
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  89.42

PubMed score by year
PubTator Score  31.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer