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Tbio
UPF3A
Regulator of nonsense transcripts 3A

Protein Summary
Description
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon j ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351487
  • ENSP00000329592
  • ENSG00000169062
  • ENST00000375299
  • ENSP00000364448

Symbol
  • RENT3A
  • UPF3
  • UPF3
  • HUPF3A
  • RENT3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
disease perturbation
0.87
transcription factor perturbation
0.84
co-expressed gene
0.79
histone modification site profile
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.93   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.93   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (181)
HBB
Tbio
Novelty:  0.00049683
p_int:  0.999999906
p_ni:  9.4e-8
Score:  0.395
Data Source:  BioPlex,STRINGDB
CA1
Tclin
Family:  Enzyme
Novelty:  0.00055482
p_int:  0.999999852
p_ni:  1.46e-7
p_wrong:  2e-9
Score:  0.379
Data Source:  BioPlex,STRINGDB
HBA1
Tclin
Novelty:  0.00094113
p_int:  0.999991122
p_ni:  0.000008878
Data Source:  BioPlex
HBD
Tbio
Novelty:  0.00203187
p_int:  0.999978689
p_ni:  0.000021311
Score:  0.219
Data Source:  BioPlex,STRINGDB
CASC3
Tbio
Novelty:  0.03935581
p_int:  0.999962762
p_ni:  0.000037238
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
AGGF1
Tbio
Novelty:  0.02757407
p_int:  0.999918341
p_ni:  0.000080668
p_wrong:  9.91e-7
Score:  0.2
Data Source:  BioPlex,STRINGDB
APOA1
Tbio
Novelty:  0.0001216
p_int:  0.979567567
p_ni:  0.02043017
p_wrong:  0.000002263
Score:  0.169
Data Source:  BioPlex,STRINGDB
SERPINA1
Tbio
Novelty:  0.00014098
p_int:  0.967742578
p_ni:  0.032172088
p_wrong:  0.000085333
Score:  0.177
Data Source:  BioPlex,STRINGDB
RNPS1
Tbio
Novelty:  0.03203224
p_int:  0.841091488
p_ni:  0.158908506
p_wrong:  6e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
LONP1
Tbio
Family:  Enzyme
Novelty:  0.00334137
p_int:  0.815787625
p_ni:  0.184212375
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Metabolism of RNA
Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Reactome
Nonsense-Mediated Decay (NMD)
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Metabolism of RNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
82
eosinophil count
2
2
2
78.2
eosinophil percentage of leukocytes
1
1
1
68.3
BMI-adjusted hip circumference
1
2
2
45.6
lymphocyte count
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
82
eosinophil count
2
78.2
eosinophil percentage of leukocytes
1
68.3
BMI-adjusted hip circumference
2
45.6
lymphocyte count
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
UPF3A, regulator of nonsense mediated mRNA decay
716601
Mouse
MGI:1914281
67031
Rat
RGD:1308778
361176
Dog
UPF3A, regulator of nonsense mediated mRNA decay
VGNC:48152
607836
Horse
UPF3A, regulator of nonsense mediated mRNA decay
VGNC:24806
100069294
Species
Name
OMA
EggNOG
Inparanoid
Macaque
UPF3A, regulator of nonsense mediated mRNA decay
Mouse
Rat
Dog
UPF3A, regulator of nonsense mediated mRNA decay
Horse
UPF3A, regulator of nonsense mediated mRNA decay
Publication Statistics
PubMed Score 61.93
PubMed score by year
PubTator Score 28.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title