You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ASCC2
Activating signal cointegrator 1 complex subunit 2

Protein Summary
Description
Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307790
  • ENSP00000305502
  • ENSG00000100325
  • ENST00000397771
  • ENSP00000380877
  • ENST00000542393
  • ENSP00000437570

Symbol
  • ASC1P100
  • p100
  • ASC1p100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
transcription factor perturbation
0.68
transcription factor binding site profile
0.65
kinase perturbation
0.6
transcription factor
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.38   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.38   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
ASCC1
Tbio
Novelty:  0.1280098
p_int:  1
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
TRIP4
Tbio
Novelty:  0.06089355
p_int:  0.999999967
p_ni:  4e-9
p_wrong:  2.9e-8
Score:  0.994
Data Source:  BioPlex,STRINGDB
ASCC3
Tbio
Novelty:  0.1303631
p_int:  0.999992009
p_ni:  0.000007991
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
ALKBH3
Tchem
Family:  Enzyme
Novelty:  0.02040675
p_int:  0.999780499
p_ni:  0.0002195
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
NOG
Tbio
Novelty:  0.0010373
p_int:  0.999571127
p_ni:  0.000428872
p_wrong:  1e-9
Data Source:  BioPlex
DGKZ
Tchem
Family:  Enzyme
Novelty:  0.01312044
p_int:  0.989987196
p_ni:  0.010012706
p_wrong:  9.8e-8
Data Source:  BioPlex
RPS13
Tbio
Novelty:  0.0019983
p_int:  0.98036394
p_ni:  0.019635979
p_wrong:  8.1e-8
Data Source:  BioPlex
CWF19L1
Tbio
Novelty:  0.1467981
Score:  0.753
Data Source:  STRINGDB
KANSL2
Tbio
Novelty:  0.08741608
Score:  0.728
Data Source:  STRINGDB
CRNKL1
Tbio
Novelty:  0.10274174
Score:  0.719
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
ALKBH3 mediated reversal of alkylation damage (R-HSA-112126)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ALKBH3 mediated reversal of alkylation damage
Reactome
DNA Damage Reversal
Reactome
DNA Repair
Reactome
Reversal of alkylation damage by DNA dioxygenases
Name
Explore in Pharos
Explore in Source
ALKBH3 mediated reversal of alkylation damage
DNA Damage Reversal
DNA Repair
Reversal of alkylation damage by DNA dioxygenases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
83.7
tonsillectomy risk measurement
1
1
0
1.1
82.6
type 2 diabetes mellitus
2
1
0
1.1
74.8
educational attainment
1
1
1
70.5
reticulocyte measurement
2
2
2
70
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
83.7
tonsillectomy risk measurement
0
1.1
82.6
type 2 diabetes mellitus
0
1.1
74.8
educational attainment
1
70.5
reticulocyte measurement
2
70
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activating signal cointegrator 1 complex subunit 2
VGNC:5225
458747
Macaque
activating signal cointegrator 1 complex subunit 2
715117
Mouse
MGI:1922702
75452
Rat
RGD:1561422
498402
Dog
activating signal cointegrator 1 complex subunit 2
VGNC:38171
486348
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activating signal cointegrator 1 complex subunit 2
Macaque
activating signal cointegrator 1 complex subunit 2
Mouse
Rat
Dog
activating signal cointegrator 1 complex subunit 2
Publication Statistics
PubMed Score 10.38
PubMed score by year
PubTator Score 1.50
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title