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Tbio
POLR3F
DNA-directed RNA polymerase III subunit RPC6

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA) (PubMed:21358628). The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB9 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377603
  • ENSP00000366828
  • ENSG00000132664

Symbol
  • RPC6
  • RPC39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
tissue sample
0.68
cellular component
0.67
biological process
0.66
co-expressed gene
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.49   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.49   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
50.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
50.8
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit F
VGNC:9941
458117
Macaque
RNA polymerase III subunit F
697927
Mouse
MGI:1924086
70408
Rat
RGD:1306428
311487
Dog
RNA polymerase III subunit F
VGNC:44804
477143
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit F
Macaque
RNA polymerase III subunit F
Mouse
Rat
Dog
RNA polymerase III subunit F
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H1D9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Gene expression (Transcription)
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
Gene expression (Transcription)
Immune System
Innate Immune System
RNA Polymerase III Abortive And Retractive Initiation
Protein-Protein Interactions (206)
1 – 10 of 206
POLR3GL
Tdark
Family: Enzyme
Novelty: 0.35648533
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
POLR3K
Tbio
Family: Enzyme
Novelty: 0.07105011
p_int: 0.999999987
p_ni: 1.3e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR3D
Tbio
Family: Enzyme
Novelty: 0.02616321
p_int: 0.999999979
p_ni: 2e-8
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR1C
Tbio
Family: Enzyme
Novelty: 0.04485332
p_int: 0.999999823
p_ni: 1.77e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR3E
Tbio
Family: Enzyme
Novelty: 0.06500715
p_int: 0.999964292
p_ni: 0.000035699
p_wrong: 8e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR2E
Tbio
Family: Enzyme
Novelty: 0.01817288
p_int: 0.999959409
p_ni: 0.00004055
p_wrong: 4.1e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
BBOX1
Tchem
Family: Enzyme
Novelty: 0.00255489
p_int: 0.999799121
p_ni: 0.00020082
p_wrong: 5.9e-8
Score: 0.325
Data Source: BioPlex,STRINGDB
MAF1
Tbio
Family: Enzyme
Novelty: 0.01060279
p_int: 0.999471167
p_ni: 0.000353867
p_wrong: 0.000174966
Score: 0.529
Data Source: BioPlex,STRINGDB
POLR3B
Tbio
Family: Enzyme
Novelty: 0.02526167
Score: 0.999
Data Source: STRINGDB
POLR3A
Tbio
Family: Enzyme
Novelty: 0.01508849
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.49

PubMed score by year
PubTator Score  7.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer