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Tchem
TRPV6
Transient receptor potential cation channel subfamily V member 6

Protein Summary
Description
Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-termina ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000638686
  • ENSP00000492723
  • ENSG00000165125

Symbol
  • ECAC2
  • CAT1
  • CATL
  • ZFAB
  • ECAC2
  • ABP/ZF
  • HRPTTN
  • LP6728
  • HSA277909
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.79
cellular component
0.7
molecular function
0.7
biological term
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.19   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.19   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (11)
ruthenium red
no chemical structure image available
CHEMBL4228250
Rendered image for CHEMBL4228250
CHEMBL4435596
Rendered image for CHEMBL4435596
CHEMBL4448267
Rendered image for CHEMBL4448267
CHEMBL4470714
Rendered image for CHEMBL4470714
CHEMBL4579017
Rendered image for CHEMBL4579017
CHEMBL2386186
Rendered image for CHEMBL2386186
CHEMBL2386185
Rendered image for CHEMBL2386185
Protein-Protein Interactions (95)
PTPN1
Tchem
Family:  Enzyme
Novelty:  0.00065779
Score:  0.963
Data Source:  STRINGDB
NIPSNAP1
Tbio
Novelty:  0.11810998
Score:  0.96
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.917
Data Source:  STRINGDB
FGR
Tchem
Family:  Kinase
Novelty:  0.00262848
Score:  0.91
Data Source:  STRINGDB
BLK
Tchem
Family:  Kinase
Novelty:  0.00480349
Score:  0.908
Data Source:  STRINGDB
YES1
Tclin
Family:  Kinase
Novelty:  0.00534936
Score:  0.908
Data Source:  STRINGDB
LCK
Tclin
Family:  Kinase
Novelty:  0.00058377
Score:  0.907
Data Source:  STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.907
Data Source:  STRINGDB
HCK
Tclin
Family:  Kinase
Novelty:  0.00237485
Score:  0.906
Data Source:  STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.905
Data Source:  STRINGDB
Pathways (12)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
16
0
1.7
93.6
reticulocyte measurement
2
2
3
80.6
reticulocyte count
4
2
4
79.4
HbA1c measurement
1
1
1
35
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
93.6
reticulocyte measurement
3
80.6
reticulocyte count
4
79.4
HbA1c measurement
1
35
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1927259
64177
Rat
RGD:69335
114246
Dog
transient receptor potential cation channel subfamily V member 6
VGNC:47886
482745
Horse
transient receptor potential cation channel subfamily V member 6
VGNC:24568
100055509
Cow
transient receptor potential cation channel subfamily V member 6
VGNC:36402
614878
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transient receptor potential cation channel subfamily V member 6
Horse
transient receptor potential cation channel subfamily V member 6
Cow
transient receptor potential cation channel subfamily V member 6
Publication Statistics
PubMed Score 283.19
PubMed score by year
PubTator Score 184.83
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title