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Tdark
CYSTM1
Cysteine-rich and transmembrane domain-containing protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261811
  • ENSP00000261811
  • ENSG00000120306

Symbol
  • C5orf32
  • C5orf32
  • ORF1-FL49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.77
kinase perturbation
0.71
cell type or tissue
0.56
transcription factor binding site profile
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.63   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.63   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
1
3
95.1
cognitive function measurement
1
1
1
91.2
intelligence
2
2
1
5.9
51.3
worry measurement
1
1
0
5.7
19.8
low density lipoprotein cholesterol measurement
1
1
1
19.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
95.1
cognitive function measurement
1
91.2
intelligence
1
5.9
51.3
worry measurement
0
5.7
19.8
low density lipoprotein cholesterol measurement
1
19.1
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cysteine rich transmembrane module containing 1
VGNC:3963
462111
Mouse
MGI:1913310
66060
Horse
cysteine rich transmembrane module containing 1
VGNC:50303
102149680
Cow
cysteine rich transmembrane module containing 1
VGNC:50308
777789
Pig
cysteine rich transmembrane module containing 1
100521956
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cysteine rich transmembrane module containing 1
Mouse
Horse
cysteine rich transmembrane module containing 1
Cow
cysteine rich transmembrane module containing 1
Pig
cysteine rich transmembrane module containing 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H1C7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (90)
1 – 10 of 90
MFSD4A
Tdark
Novelty: 0.62186415
p_int: 0.999355655
p_ni: 0.000124259
p_wrong: 0.000520085
Score: 0.415
Data Source: BioPlex,STRINGDB
SLC39A5
Tbio
Family: Transporter
Novelty: 0.05205571
p_int: 0.998842501
p_ni: 0.000090257
p_wrong: 0.001067243
Score: 0.189
Data Source: BioPlex,STRINGDB
CYP3A7
Tclin
Family: Enzyme
Novelty: 0.00736888
p_int: 0.800914751
p_ni: 0.002910154
p_wrong: 0.196175096
Data Source: BioPlex
TSPAN14
Tdark
Novelty: 0.31693614
Score: 0.902
Data Source: STRINGDB
LAMTOR2
Tbio
Novelty: 0.05210182
Score: 0.902
Data Source: STRINGDB
CD59
Tbio
Novelty: 0.0008352
Score: 0.902
Data Source: STRINGDB
SLC2A3
Tchem
Family: Transporter
Novelty: 0.00229395
Score: 0.902
Data Source: STRINGDB
ATP6V0C
Tbio
Family: Enzyme
Novelty: 0.01142874
Score: 0.902
Data Source: STRINGDB
TMEM63A
Tdark
Family: IC
Novelty: 0.33131011
Score: 0.902
Data Source: STRINGDB
SNAP23
Tbio
Novelty: 0.0065371
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.63

PubMed score by year
PubTator Score  0.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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