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Tbio
UNC93B1
Protein unc-93 homolog B1

Protein Summary
Description
Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227471
  • ENSP00000227471
  • ENSG00000110057

Symbol
  • UNC93
  • UNC93B
  • IIAE1
  • UNC93
  • UNC93B
  • Unc-93B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
cellular component
0.9
interacting protein
0.86
ligand (protein) perturbation
0.83
small molecule perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.34   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.34   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
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RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
FDFT1
Tchem
Family:  Enzyme
Novelty:  0.00225882
p_int:  0.999726218
p_ni:  0.000273772
p_wrong:  9e-9
Score:  0.309
Data Source:  BioPlex,STRINGDB
SEMA7A
Tbio
Novelty:  0.00741605
p_int:  0.999720777
p_ni:  0.000239286
p_wrong:  0.000039937
Score:  0.271
Data Source:  BioPlex,STRINGDB
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.999394947
p_ni:  0.000605048
p_wrong:  5e-9
Score:  0.186
Data Source:  BioPlex,STRINGDB
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.996220458
p_ni:  0.003758935
p_wrong:  0.000020607
Data Source:  BioPlex
TLR3
Tbio
Novelty:  0.00057048
Score:  0.99
Data Source:  Reactome,STRINGDB
TLR8
Tchem
Novelty:  0.0023384
Score:  0.987
Data Source:  Reactome,STRINGDB
TLR7
Tclin
Novelty:  0.00067036
Score:  0.985
Data Source:  Reactome,STRINGDB
CNPY3
Tbio
Novelty:  0.11473132
Score:  0.968
Data Source:  STRINGDB
HSP90B1
Tchem
Novelty:  0.00135881
Score:  0.945
Data Source:  STRINGDB
TLR9
Tclin
Novelty:  0.00058868
Score:  0.836
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases associated with the TLR signaling cascade
Reactome
Diseases of Immune System
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Disease
Diseases associated with the TLR signaling cascade
Diseases of Immune System
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
3
66.6
serum non-albumin protein measurement
1
1
1
55.2
reticulocyte count
1
1
1
40.7
serum albumin measurement
1
1
1
33.1
BMI-adjusted waist circumference
1
1
1
6.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
66.6
serum non-albumin protein measurement
1
55.2
reticulocyte count
1
40.7
serum albumin measurement
1
33.1
BMI-adjusted waist circumference
1
6.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
unc-93 homolog B1, TLR signaling regulator
746130
Macaque
unc-93 homolog B1, TLR signaling regulator
710928
Mouse
MGI:1859307
54445
Rat
RGD:1311984
361689
Dog
unc-93 homolog B1, TLR signaling regulator
VGNC:49636
483692
Species
Name
OMA
EggNOG
Inparanoid
Chimp
unc-93 homolog B1, TLR signaling regulator
Macaque
unc-93 homolog B1, TLR signaling regulator
Mouse
Rat
Dog
unc-93 homolog B1, TLR signaling regulator
Publication Statistics
PubMed Score 78.34
PubMed score by year
PubTator Score 34.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title