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Tchem
LPAR5
Lysophosphatidic acid receptor 5

Protein Summary
Description
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329858
  • ENSP00000327875
  • ENSG00000184574
  • ENST00000431922
  • ENSP00000393098

Symbol
  • GPR92
  • GPR93
  • LPA5
  • GPR92
  • GPR93
  • KPG_010
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.61
microRNA
0.58
transcription factor
0.53
cell type or tissue
0.45
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.47   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.47   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 80
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (16)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (377)
1 – 10 of 377
LPAR3
Tchem
Family: GPCR
Novelty: 0.00724581
Score: 0.987
Data Source: STRINGDB
LPAR2
Tchem
Family: GPCR
Novelty: 0.01023607
Score: 0.987
Data Source: STRINGDB
LPAR1
Tchem
Family: GPCR
Novelty: 0.004102
Score: 0.985
Data Source: STRINGDB
P2RY10
Tchem
Family: GPCR
Novelty: 0.30443923
Score: 0.958
Data Source: STRINGDB
GPRC6A
Tchem
Family: GPCR
Novelty: 0.02008511
Score: 0.958
Data Source: STRINGDB
TAS1R1
Tbio
Family: GPCR
Novelty: 0.0152692
Score: 0.955
Data Source: STRINGDB
TAS1R3
Tbio
Family: GPCR
Novelty: 0.0050744
Score: 0.951
Data Source: STRINGDB
S1PR4
Tclin
Family: GPCR
Novelty: 0.01383323
Score: 0.949
Data Source: STRINGDB
TAS1R2
Tbio
Family: GPCR
Novelty: 0.00853435
Score: 0.947
Data Source: STRINGDB
S1PR5
Tclin
Family: GPCR
Novelty: 0.01904383
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  34.47

PubMed score by year
PubTator Score  30.01

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLL
1-70
FTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARL
70-140
LCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYS
140-210
SGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLM
210-280
VMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQG
280-350
LLRPSDSHSLSSFTQCPQDSAL
350-372
MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL