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Tbio
SDCBP2
Syntenin-2

Protein Summary
Description
Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997). The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339987
  • ENSP00000342935
  • ENSG00000125775
  • ENST00000360779
  • ENSP00000354013
  • ENST00000381808
  • ENSP00000371229
  • ENST00000381812
  • ENSP00000371233

Symbol
  • SITAC18
  • ST2
  • ST-2
  • SITAC
  • SITAC18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
1
gene perturbation
0.65
transcription factor
0.62
cell type or tissue
0.58
tissue sample
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.15   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.15   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (16)
LYAR
Tbio
Novelty:  0.04324088
Score:  0.731
Data Source:  STRINGDB
LINS1
Tbio
Novelty:  0.00317377
Score:  0.569
Data Source:  STRINGDB
MYO7B
Tbio
Novelty:  0.10660261
Score:  0.554
Data Source:  STRINGDB
TM4SF1
Tbio
Novelty:  0.02410436
Score:  0.554
Data Source:  STRINGDB
FAM71B
Tdark
Novelty:  0.78218068
Score:  0.511
Data Source:  STRINGDB
ZCCHC17
Tbio
Novelty:  0.06999007
Score:  0.511
Data Source:  STRINGDB
PRPF40A
Tbio
Novelty:  0.00898047
Score:  0.511
Data Source:  STRINGDB
EXOC2
Tbio
Novelty:  0.01434464
Score:  0.498
Data Source:  STRINGDB
CNTN2
Tbio
Novelty:  0.00213251
Score:  0.486
Data Source:  STRINGDB
NFASC
Tbio
Novelty:  0.00545331
Score:  0.433
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
2
2
74.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
74.1
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syndecan binding protein 2
VGNC:6261
749345
Macaque
syndecan binding protein 2
715602
Mouse
MGI:2385156
228765
Rat
RGD:1307709
311532
Dog
syndecan binding protein 2
VGNC:45945
485811
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syndecan binding protein 2
Macaque
syndecan binding protein 2
Mouse
Rat
Dog
syndecan binding protein 2
Publication Statistics
PubMed Score 10.15
PubMed score by year
PubTator Score 8.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title