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Tbio
ABCG4
ATP-binding cassette sub-family G member 4

Protein Summary
Description
May be involved in macrophage lipid homeostasis. The protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein is a member of the White subfamily and plays an important role in cellular cholesterol homeostasis. This protein functions as either a homodimer or as a heterodimer with another ABC subfamily protein such as ABCG1. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000615496
  • ENSP00000479253
  • ENSG00000172350
  • ENST00000619701
  • ENSP00000481728
  • ENST00000622721
  • ENSP00000484289

Symbol
  • WHITE2
  • WHITE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
histone modification site profile
0.74
protein domain
0.73
PubMedID
0.54
tissue
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.68   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.68   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
2
2
2
49.5
monocyte percentage of leukocytes
1
1
1
24.9
lymphocyte count
1
1
1
10.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
2
49.5
monocyte percentage of leukocytes
1
24.9
lymphocyte count
1
10.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1890594
192663
Rat
RGD:1305840
300664
Dog
ATP binding cassette subfamily G member 4
VGNC:37453
610604
Horse
ATP binding cassette subfamily G member 4
VGNC:14930
100146118
Cow
ATP binding cassette subfamily G member 4
VGNC:25484
508443
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ATP binding cassette subfamily G member 4
Horse
ATP binding cassette subfamily G member 4
Cow
ATP binding cassette subfamily G member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H172-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
ABC transporters in lipid homeostasis (R-HSA-1369062)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Transport of small molecules
Gene Ontology Terms (12)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (46)
1 – 10 of 46
ABCC11
Tbio
Family: Transporter
Novelty: 0.01382192
Score: 0.918
Data Source: STRINGDB
ABCC5
Tchem
Family: Transporter
Novelty: 0.00566605
Score: 0.847
Data Source: STRINGDB
ABCC3
Tbio
Family: Transporter
Novelty: 0.00260166
Score: 0.758
Data Source: STRINGDB
RUSC2
Tbio
Novelty: 0.14691927
Score: 0.715
Data Source: STRINGDB
ABCF3
Tdark
Family: Transporter
Novelty: 0.21595418
Score: 0.707
Data Source: STRINGDB
ABCC4
Tchem
Family: Transporter
Novelty: 0.00208051
Score: 0.703
Data Source: STRINGDB
ABCC2
Tchem
Family: Transporter
Novelty: 0.00110828
Score: 0.7
Data Source: STRINGDB
AMN
Tbio
Novelty: 0.030358
Score: 0.673
Data Source: STRINGDB
ABCF2
Tbio
Family: Transporter
Novelty: 0.06782708
Score: 0.668
Data Source: STRINGDB
CUBN
Tbio
Novelty: 0.00441944
Score: 0.659
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.68

PubMed score by year
PubTator Score  24.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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