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Tbio
ZBP1
Z-DNA-binding protein 1

Protein Summary
Description
Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371173
  • ENSP00000360215
  • ENSG00000124256
  • ENST00000395822
  • ENSP00000379167
  • ENST00000541799
  • ENSP00000440552

Symbol
  • C20orf183
  • DLM1
  • DAI
  • DLM1
  • DLM-1
  • C20orf183
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.66
gene perturbation
0.63
molecular function
0.6
disease
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.01   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.01   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
IRF3 mediated activation of type 1 IFN
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RIP-mediated NFkB activation via ZBP1
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
IRF3 mediated activation of type 1 IFN
Immune System
Innate Immune System
RIP-mediated NFkB activation via ZBP1
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
IntAct
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (66)
1 – 10 of 66
TBK1
Tchem
Family: Kinase
Novelty: 0.00194753
Score: 0.969
Data Source: Reactome,STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00099474
Score: 0.968
Data Source: Reactome,STRINGDB
RIPK3
Tchem
Family: Kinase
Novelty: 0.00326006
Score: 0.965
Data Source: Reactome,STRINGDB
RIPK1
Tchem
Family: Kinase
Novelty: 0.00230565
Score: 0.958
Data Source: Reactome,STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.945
Data Source: STRINGDB
IKBKB
Tchem
Family: Kinase
Novelty: 0.00090202
Score: 0.939
Data Source: STRINGDB
CHUK
Tchem
Family: Kinase
Novelty: 0.00151532
Score: 0.937
Data Source: STRINGDB
NFKB1
Tclin
Family: TF
Novelty: 0.00198195
Score: 0.925
Data Source: STRINGDB
RELA
Tchem
Family: TF
Novelty: 0.0007137
Score: 0.922
Data Source: STRINGDB
NFKB2
Tchem
Family: TF
Novelty: 0.00366074
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  96.01

PubMed score by year
PubTator Score  79.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer