BCL11A
B-cell lymphoma/leukemia 11A
Protein Summary
Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level (PubMed:26375765). Involved in brain development (PubMed:27453576). Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity). This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple ...more
- ENST00000335712
- ENSP00000338774
- ENSG00000119866
- ENST00000356842
- ENSP00000349300
- ENST00000359629
- ENSP00000352648
- ENST00000409351
- ENSP00000487844
- ENST00000642384
- ENSP00000496168
- CTIP1
- EVI9
- KIAA1809
- ZNF856
- EVI9
- CTIP1
- DILOS
- ZNF856
- HBFQTL5
- BCL11A-L
- BCL11A-S
- BCL11a-M
- BCL11A-XL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 1 | ||
transcription factor perturbation | 1 | ||
molecular function | 0.91 | ||
microRNA | 0.86 | ||
transcription factor binding site profile | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 320.68 (req: < 5)
Gene RIFs: 125 (req: <= 3)
Antibodies: 417 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 320.68 (req: >= 5)
Gene RIFs: 125 (req: > 3)
Antibodies: 417 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0