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Tbio
BCL11A
B-cell lymphoma/leukemia 11A

Protein Summary
Description
Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level (PubMed:26375765). Involved in brain development (PubMed:27453576). Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity). This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335712
  • ENSP00000338774
  • ENSG00000119866
  • ENST00000356842
  • ENSP00000349300
  • ENST00000359629
  • ENSP00000352648
  • ENST00000409351
  • ENSP00000487844
  • ENST00000642384
  • ENSP00000496168

Symbol
  • CTIP1
  • EVI9
  • KIAA1809
  • ZNF856
  • EVI9
  • CTIP1
  • DILOS
  • ZNF856
  • HBFQTL5
  • BCL11A-L
  • BCL11A-S
  • BCL11a-M
  • BCL11A-XL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
1
molecular function
0.91
microRNA
0.86
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.68   (req: < 5)
Gene RIFs: 124   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.68   (req: >= 5)
Gene RIFs: 124   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0