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Tbio
SLITRK2
SLIT and NTRK-like protein 2

Protein Summary
Description
It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Suppresses neurite outgrowth (By similarity). This gene encodes an integral membrane protein that contains two N-terminal leucine-rich repeats domains and contains C-terminal regions similar to neurotrophin receptors. The encoded protein may play a role in modulating neurite activity. Alternatively spliced transcript variants encoding the same protein have been described.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370490
  • ENSP00000359521
  • ENSG00000185985

Symbol
  • CXorf2
  • KIAA1854
  • SLITL1
  • CXorf1
  • CXorf2
  • SLITL1
  • TMEM257
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.65
virus perturbation
0.64
tissue sample
0.6
protein domain
0.58
cell line
0.51


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.94   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.94   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SLIT and NTRK like family member 2
699766
Mouse
MGI:2679449
245450
Rat
RGD:1561361
309349
Dog
SLIT and NTRK like family member 2
VGNC:46507
492190
Horse
SLIT and NTRK like family member 2
VGNC:23301
100055684
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SLIT and NTRK like family member 2
Mouse
Rat
Dog
SLIT and NTRK like family member 2
Horse
SLIT and NTRK like family member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H156-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Receptor-type tyrosine-protein phosphatases
Name
Explore in Pharos
Explore in Source
Neuronal System
Protein-protein interactions at synapses
Receptor-type tyrosine-protein phosphatases
Protein-Protein Interactions (50)
1 – 10 of 50
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
Score:  0.983
Data Source:  STRINGDB
PTPRS
Tchem
Family:  Enzyme
Novelty:  0.00587115
Score:  0.861
Data Source:  STRINGDB
PTPRF
Tchem
Family:  Enzyme
Novelty:  0.01017327
Score:  0.848
Data Source:  STRINGDB
PTPRA
Tchem
Family:  Enzyme
Novelty:  0.01392344
Score:  0.73
Data Source:  STRINGDB
PTPRE
Tbio
Family:  Enzyme
Novelty:  0.04184946
Score:  0.73
Data Source:  STRINGDB
TMEM164
Tdark
Novelty:  1.0284366
Score:  0.68
Data Source:  STRINGDB
HDC
Tbio
Family:  Enzyme
Novelty:  0.00193646
Score:  0.647
Data Source:  STRINGDB
IGHMBP2
Tbio
Novelty:  0.01054517
Score:  0.647
Data Source:  STRINGDB
TBCD
Tbio
Novelty:  0.01161221
Score:  0.64
Data Source:  STRINGDB
IMMP2L
Tbio
Family:  Enzyme
Novelty:  0.03566408
Score:  0.625
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4.94

PubMed score by year
PubTator Score  3.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer