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Tbio
DNTTIP1
Deoxynucleotidyltransferase terminal-interacting protein 1

Protein Summary
Description
Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA. DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372622
  • ENSP00000361705
  • ENSG00000101457

Symbol
  • C20orf167
  • TDIF1
  • Tdif1
  • C20orf167
  • dJ447F3.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
histone modification site profile
0.8
transcription factor binding site profile
0.78
kinase perturbation
0.76
cell type or tissue
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.14   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.14   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipid measurement
1
1
1
80.3
mean platelet volume
2
1
2
79.9
triglyceride measurement
1
2
2
71.8
serum metabolite measurement
2
1
11
61
low density lipoprotein cholesterol measurement
1
1
1
56.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipid measurement
1
80.3
mean platelet volume
2
79.9
triglyceride measurement
2
71.8
serum metabolite measurement
11
61
low density lipoprotein cholesterol measurement
1
56.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deoxynucleotidyltransferase terminal interacting protein 1
VGNC:13846
469955
Macaque
deoxynucleotidyltransferase terminal interacting protein 1
709468
Mouse
MGI:1923483
76233
Rat
RGD:621627
171437
Dog
deoxynucleotidyltransferase terminal interacting protein 1
VGNC:40040
477246
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deoxynucleotidyltransferase terminal interacting protein 1
Macaque
deoxynucleotidyltransferase terminal interacting protein 1
Mouse
Rat
Dog
deoxynucleotidyltransferase terminal interacting protein 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H147-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (85)
1 – 10 of 85
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  1
Score:  0.948
Data Source:  BioPlex,STRINGDB
WDFY2
Tbio
Novelty:  0.01835759
p_int:  0.99998584
p_ni:  0.000013961
p_wrong:  1.99e-7
Score:  0.202
Data Source:  BioPlex,STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
p_int:  0.999657814
p_ni:  0.000070303
p_wrong:  0.000271883
Score:  0.246
Data Source:  BioPlex,STRINGDB
PHOSPHO2
Tdark
Family:  Enzyme
Novelty:  0.36911271
p_int:  0.999632274
p_ni:  0.000070165
p_wrong:  0.000297561
Score:  0.379
Data Source:  BioPlex,STRINGDB
HDAC3
Tclin
Family:  Epigenetic
Novelty:  0.00393172
Score:  0.946
Data Source:  STRINGDB
HDAC2
Tclin
Family:  Epigenetic
Novelty:  0.0011024
Score:  0.944
Data Source:  STRINGDB
TRERF1
Tbio
Family:  TF
Novelty:  0.14145497
Score:  0.935
Data Source:  STRINGDB
HDAC9
Tclin
Family:  Epigenetic
Novelty:  0.00382278
Score:  0.918
Data Source:  STRINGDB
HDAC8
Tclin
Family:  Epigenetic
Novelty:  0.0023827
Score:  0.917
Data Source:  STRINGDB
ZNF541
Tdark
Family:  TF
Novelty:  1.64949592
Score:  0.916
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.14

PubMed score by year
PubTator Score  3.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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