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Tbio
RBM38
RNA-binding protein 38

Protein Summary
Description
RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. (Microbial infection) Essential factor for the splicing of the pre-mRNAs of human parvovirus B19 (B19V) and for the expression of B19V 11-kDa protein, which enhances viral replication.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356208
  • ENSP00000348538
  • ENSG00000132819
  • ENST00000440234
  • ENSP00000407848

Symbol
  • RNPC1
  • SEB4
  • RNPC1
  • SEB4B
  • SEB4D
  • HSRNASEB
  • dJ800J21.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
transcription factor perturbation
0.84
transcription factor
0.7
tissue sample
0.64
disease
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.98   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.98   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (77)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
8
13
98.4
mean reticulocyte volume
1
4
4
98.3
mean corpuscular volume
4
4
5
98.1
reticulocyte measurement
3
6
8
97.8
mean platelet volume
3
3
4
91.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
13
98.4
mean reticulocyte volume
4
98.3
mean corpuscular volume
5
98.1
reticulocyte measurement
8
97.8
mean platelet volume
4
91.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RNA binding motif protein 38
696583
Mouse
MGI:1889294
56190
Rat
RGD:1308503
366262
Dog
RNA binding motif protein 38
VGNC:54726
611796
Horse
RNA binding motif protein 38
VGNC:51597
100146683
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RNA binding motif protein 38
Mouse
Rat
Dog
RNA binding motif protein 38
Horse
RNA binding motif protein 38
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H0Z9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (60)
1 – 10 of 60
RBM24
Tbio
Novelty:  0.04562076
p_int:  0.999997915
p_ni:  0.000002076
p_wrong:  8e-9
Score:  0.249
Data Source:  BioPlex,STRINGDB
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.999958089
p_ni:  0.000041318
p_wrong:  5.94e-7
Score:  0.576
Data Source:  BioPlex,STRINGDB
TMEM184A
Tbio
Novelty:  0.16408207
p_int:  0.99882614
p_ni:  0.001166145
p_wrong:  0.000007715
Score:  0.165
Data Source:  BioPlex,STRINGDB
CLASRP
Tbio
Novelty:  0.00582947
p_int:  0.895961132
p_ni:  0.005423323
p_wrong:  0.098615545
Score:  0.421
Data Source:  BioPlex,STRINGDB
PTCD3
Tbio
Novelty:  0.12368434
p_int:  0.80792706
p_ni:  0.035244583
p_wrong:  0.156828357
Score:  0.169
Data Source:  BioPlex,STRINGDB
ELAVL1
Tchem
Novelty:  0.00110045
Score:  0.854
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.705
Data Source:  STRINGDB
CTCFL
Tbio
Family:  TF
Novelty:  0.00858527
Score:  0.695
Data Source:  STRINGDB
PHACTR3
Tbio
Family:  Enzyme
Novelty:  0.09524691
Score:  0.677
Data Source:  STRINGDB
PCBP4
Tbio
Novelty:  0.03763262
Score:  0.667
Data Source:  STRINGDB
Publication Statistics
PubMed Score  43.98

PubMed score by year
PubTator Score  21.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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