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Tbio
RAB1B
Ras-related protein Rab-1B

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 1280 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311481
  • ENSP00000310226
  • ENSG00000174903
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.92
molecular function
0.91
tissue
0.83
histone modification site profile
0.82
virus perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.65   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.65   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
1
1
0
1
73.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
0
1
73.5
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1923558
76308
Dog
RAB1B, member RAS oncogene family
VGNC:52037
610762
Horse
RAB1B, member RAS oncogene family
100058091
Cow
RAB1B, member RAS oncogene family
540685
Opossum
RAB1B, member RAS oncogene family
100015981
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
RAB1B, member RAS oncogene family
Horse
RAB1B, member RAS oncogene family
Cow
RAB1B, member RAS oncogene family
Opossum
RAB1B, member RAS oncogene family
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H0U4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
COPII-mediated vesicle transport
Cell Cycle
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (324)
1 – 10 of 324
RAB1A
Tbio
Family: Enzyme
Novelty: 0.00307527
p_int: 1
Score: 0.985
Data Source: BioPlex,STRINGDB
GDI1
Tbio
Novelty: 0.01710945
p_int: 0.999998117
p_ni: 0.000001883
Score: 0.993
Data Source: BioPlex,STRINGDB
RAB8B
Tbio
Family: Enzyme
Novelty: 0.06230082
p_int: 0.999970182
p_ni: 0.000029798
p_wrong: 2e-8
Score: 0.99
Data Source: BioPlex,STRINGDB
CHML
Tbio
Family: Enzyme
Novelty: 0.00509709
p_int: 0.999864824
p_ni: 0.000135174
p_wrong: 2e-9
Score: 0.979
Data Source: BioPlex,STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
p_int: 0.999806946
p_ni: 0.000193054
Score: 0.979
Data Source: BioPlex,STRINGDB
GDI2
Tbio
Novelty: 0.02861013
p_int: 0.99979229
p_ni: 0.00020771
Score: 0.997
Data Source: BioPlex,STRINGDB
RABGGTA
Tdark
Family: Enzyme
Novelty: 0.19962321
p_int: 0.981700923
p_ni: 0.018299077
Score: 0.982
Data Source: BioPlex,STRINGDB
RAB2B
Tdark
Family: Enzyme
Novelty: 0.18567584
p_int: 0.940732465
p_ni: 0.059267535
Score: 0.966
Data Source: BioPlex,STRINGDB
TMEM159
Tdark
Novelty: 0.22237677
p_int: 0.936676823
p_ni: 0.063323177
Data Source: BioPlex
RABIF
Tbio
Novelty: 0.22512579
p_int: 0.901020004
p_ni: 0.098979995
p_wrong: 2e-9
Score: 0.911
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  48.65

PubMed score by year
PubTator Score  28.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer