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Tbio
MAGT1
Magnesium transporter protein 1

Protein Summary
Description
Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. May be involved in Mg(2+) transport in epithelial cells. This gene encodes a ubiquitously expressed magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosacc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373336
  • ENSP00000362433
  • ENSG00000102158
  • ENST00000618282
  • ENSP00000480732

Symbol
  • IAG2
  • IAP
  • XMEN
  • MRX95
  • OST3B
  • PRO0756
  • bA217H1.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor perturbation
0.88
kinase perturbation
0.81
interacting protein
0.65
cellular component
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.6   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.6   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
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RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (167)
1 – 10 of 167
STT3B
Tbio
Family:  Enzyme
Novelty:  0.05813174
Score:  0.999
Data Source:  STRINGDB
DDOST
Tchem
Family:  Enzyme
Novelty:  0.01797594
Score:  0.999
Data Source:  STRINGDB
RPN2
Tbio
Family:  Enzyme
Novelty:  0.01796569
Score:  0.997
Data Source:  STRINGDB
STT3A
Tbio
Family:  Enzyme
Novelty:  0.01063504
Score:  0.995
Data Source:  STRINGDB
DAD1
Tbio
Family:  Enzyme
Novelty:  0.00653242
Score:  0.993
Data Source:  STRINGDB
RPN1
Tbio
Family:  Enzyme
Novelty:  0.00880101
Score:  0.993
Data Source:  STRINGDB
SEC61A1
Tbio
Novelty:  0.0026034
Score:  0.969
Data Source:  STRINGDB
SSR3
Tbio
Novelty:  0.05838475
Score:  0.968
Data Source:  STRINGDB
SSR4
Tbio
Novelty:  0.04072695
Score:  0.956
Data Source:  STRINGDB
OST4
Tdark
Family:  Enzyme
Novelty:  0.07519513
Score:  0.95
Data Source:  STRINGDB
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Miscellaneous transport and binding events
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Immune System
Innate Immune System
Metabolism of proteins
Miscellaneous transport and binding events
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
79.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
79.8
Find similar targets by:
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
magnesium transporter 1
VGNC:14698
465726
Macaque
magnesium transporter 1
710098
Mouse
MGI:1914325
67075
Rat
RGD:620094
116967
Dog
magnesium transporter 1
VGNC:42930
491975
Species
Name
OMA
EggNOG
Inparanoid
Chimp
magnesium transporter 1
Macaque
magnesium transporter 1
Mouse
Rat
Dog
magnesium transporter 1
Publication Statistics
PubMed Score 47.60
PubMed score by year
PubTator Score 79.30
PubTator score by year