Tbio MAGT1 Magnesium transporter protein 1

Protein Summary

Description

Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. May be involved in Mg(2+) transport in epithelial cells. This gene encodes a ubiquitously expressed magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause a form of X-linked intellectual disability (XLID). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jul 2017]

Uniprot Accession IDs

• Q9H0U3
• B2RAR4
• D3DTE3
• Q53G00
• Q6P577
• Q8NBN6
• MagT1

Gene Name

• MAGT1

Ensembl ID

• ENST00000373336
• ENSP00000362433
• ENSG00000102158
• ENST00000618282
• ENSP00000480732

Symbol

• IAG2
• IAP
• XMEN
• MRX95
• OST3B
• PRO0756
• bA217H1.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
transcription factor perturbation	0.88
kinase perturbation	0.81
interacting protein	0.65
cellular component	0.64

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Magnesium Transporter Protein 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc58 Magt-like Magnesium Transporter Family / Magnesium Transporter Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.2   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 110   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.2   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0