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Tbio
RAB17
Ras-related protein Rab-17

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264601
  • ENSP00000264601
  • ENSG00000124839
  • ENST00000409822
  • ENSP00000386589
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
cellular component
0.76
transcription factor perturbation
0.74
interacting protein
0.71
biological process
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.31   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.31   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
p_int:  0.999882594
p_ni:  0.000117406
Score:  0.941
Data Source:  BioPlex,STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
p_int:  0.999734853
p_ni:  0.000265146
p_wrong:  1e-9
Score:  0.941
Data Source:  BioPlex,STRINGDB
MOCS1
Tclin
Novelty:  0.02785369
p_int:  0.991968868
p_ni:  0.007935728
p_wrong:  0.000095404
Score:  0.239
Data Source:  BioPlex,STRINGDB
BOLA1
Tbio
Novelty:  0.1092583
p_int:  0.963551898
p_ni:  0.03346628
p_wrong:  0.002981823
Score:  0.255
Data Source:  BioPlex,STRINGDB
GTPBP1
Tbio
Novelty:  0.00160825
p_int:  0.83027605
p_ni:  0.16972395
Score:  0.345
Data Source:  BioPlex,STRINGDB
GEMIN6
Tbio
Novelty:  0.02104816
p_int:  0.802556269
p_ni:  0.197443522
p_wrong:  2.08e-7
Score:  0.219
Data Source:  BioPlex,STRINGDB
RAB7A
Tchem
Family:  Enzyme
Novelty:  0.00192702
Score:  0.957
Data Source:  STRINGDB
RAB7B
Tbio
Family:  Enzyme
Novelty:  0.00207354
Score:  0.933
Data Source:  STRINGDB
RAB9A
Tbio
Family:  Enzyme
Novelty:  0.07006531
Score:  0.932
Data Source:  STRINGDB
RAB9B
Tbio
Family:  Enzyme
Novelty:  0.19952686
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
4
78.2
5
4
0
1.1
64.8
central corneal thickness
1
1
0
1.6
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
78.2
0
1.1
64.8
central corneal thickness
0
1.6
17.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB17, member RAS oncogene family
VGNC:2795
745679
Macaque
RAB17, member RAS oncogene family
703609
Mouse
MGI:104640
19329
Rat
RGD:1562478
503269
Dog
RAB17, member RAS oncogene family
VGNC:45256
607120
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB17, member RAS oncogene family
Macaque
RAB17, member RAS oncogene family
Mouse
Rat
Dog
RAB17, member RAS oncogene family
Publication Statistics
PubMed Score 28.31
PubMed score by year
PubTator Score 10.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title