Tbio QRSL1 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

Protein Summary

Description

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

Uniprot Accession IDs

• Q9H0R6
• Q5VWJ4
• Q9HA60
• Q9NV19
• Glu-AdT subunit A

Gene Name

• QRSL1

Ensembl ID

• ENST00000369046
• ENSP00000358042
• ENSG00000130348

Symbol

• GatA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
kinase perturbation	0.96
histone modification site profile	0.91
molecular function	0.86
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Glutamyl-trna(gln) Amidotransferase Subunit A, Mitochondrial

Protein / Ligase / Glutamyl-trna(gln) Amidotransferase Subunit A, Mitochondrial

Protein / Hydrolase / Glutamyl-trna(gln) Amidotransferase Subunit A, Mitochondrial

DTO Classes

Protein / Enzyme / Transferase / Glutamyl-trna(gln) Amidotransferase Subunit A, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.6   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 144   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.6   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (75)

Explore Interacting Targets

1 – 10 of 75

• See Interactions on String-DB

GATC

Tbio

Family:  Enzyme

Novelty:  0.62484697

p_int:  1

Score:  0.983

Data Source:  BioPlex,STRINGDB

GPBP1L1

Tdark

Novelty:  0.69320833

p_int:  0.999999996

p_ni:  4e-9

Score:  0.185

Data Source:  BioPlex,STRINGDB

GATB

Tbio

Family:  Enzyme

Novelty:  0.01269151

p_int:  0.999999329

p_ni:  6.71e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

APOA2

Tbio

Novelty:  0.00117627

p_int:  0.946660553

p_ni:  0.022746433

p_wrong:  0.030593015

Data Source:  BioPlex

USP47

Tchem

Family:  Enzyme

Novelty:  0.07579226

p_int:  0.942413045

p_ni:  0.056827086

p_wrong:  0.000759869

Data Source:  BioPlex

ARSG

Tbio

Family:  Enzyme

Novelty:  0.04412917

p_int:  0.930177282

p_ni:  0.069822718

Score:  0.206

Data Source:  BioPlex,STRINGDB

NARS2

Tbio

Family:  Enzyme

Novelty:  0.01879317

Score:  0.982

Data Source:  STRINGDB

QARS

Tchem

Family:  Enzyme

Novelty:  0.01684657

Score:  0.972

Data Source:  STRINGDB

NARS

Tbio

Family:  Enzyme

Novelty:  0.01124207

Score:  0.969

Data Source:  STRINGDB

EARS2

Tbio

Family:  Enzyme

Novelty:  0.00280518

Score:  0.83

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

KEGG (2)

PathwayCommons (1)

Find Similar Targets

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1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Aminoacyl-tRNA biosynthesis	44 targets	path:hsa00970
KEGG	Metabolic pathways	1433 targets	path:hsa01100

Name	Explore in Pharos	Explore in Source
Aminoacyl-tRNA biosynthesis	44 targets	path:hsa00970
Metabolic pathways	1433 targets	path:hsa01100

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (3)

Components (2)

Processes (3)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Inferred from Direct Assay (IDA)	UniProtKB
amidase activity	Inferred from Electronic Annotation (IEA)	InterPro
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (4)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell density measurement	EFO_0007978	1	1	1		46.5
urate measurement	EFO_0004531	1	1	1		37.6
blood urea nitrogen measurement	EFO_0004741	1	1	1		17.8
glomerular filtration rate	EFO_0005208	1	1	0	5.5	15.8

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5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell density measurement	EFO_0007978	1		46.5
urate measurement	EFO_0004531	1		37.6
blood urea nitrogen measurement	EFO_0004741	1		17.8
glomerular filtration rate	EFO_0005208	0	5.5	15.8

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
ATP-binding
Complete proteome
Disease mutation
Ligase
Mitochondrion
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
blood urea nitrogen measurement
glomerular filtration rate
red blood cell density measurement
urate measurement

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1		462909
Macaque	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1		697354
Mouse	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1	MGI:1923813	76563
Rat	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1	RGD:1359490	309911
Dog	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1		475014

Species	Name	OMA	EggNOG	Inparanoid
Chimp	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Macaque	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Mouse	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Rat	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Dog	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1

Publication Statistics

PubMed Score 126.60

PubMed score by year

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PubTator Score 463.16

PubTator score by year

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Related Publications

Text Mined References (9)

GeneRif Annotations (3)

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10

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PMID	Year	Title