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Tbio
QRSL1
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

Protein Classes
Protein Summary
Description
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369046
  • ENSP00000358042
  • ENSG00000130348

Symbol
  • GatA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
kinase perturbation
0.96
histone modification site profile
0.91
molecular function
0.86
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.5   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.5   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (75)
1 – 10 of 75
GATC
Tbio
Family: Enzyme
p_int: 1
Score: 0.983
Data Source: BioPlex,STRINGDB
GPBP1L1
Tdark
Novelty: 0.23809524
p_int: 0.999999996
p_ni: 4e-9
Score: 0.185
Data Source: BioPlex,STRINGDB
GATB
Tbio
Family: Enzyme
Novelty: 0.0265185
p_int: 0.999999329
p_ni: 6.71e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
APOA2
Tbio
Novelty: 0.00133324
p_int: 0.946660553
p_ni: 0.022746433
p_wrong: 0.030593015
Data Source: BioPlex
USP47
Tchem
Family: Enzyme
Novelty: 0.12618297
p_int: 0.942413045
p_ni: 0.056827086
p_wrong: 0.000759869
Data Source: BioPlex
ARSG
Tbio
Family: Enzyme
Novelty: 0.0408666
p_int: 0.930177282
p_ni: 0.069822718
Score: 0.206
Data Source: BioPlex,STRINGDB
NARS2
Tbio
Family: Enzyme
Novelty: 0.02380757
Score: 0.982
Data Source: STRINGDB
QARS
Tchem
Family: Enzyme
Novelty: 0.02294313
Score: 0.972
Data Source: STRINGDB
NARS
Tbio
Family: Enzyme
Novelty: 0.00941326
Score: 0.969
Data Source: STRINGDB
EARS2
Tbio
Family: Enzyme
Novelty: 0.00399418
Score: 0.83
Data Source: STRINGDB
Publication Statistics
PubMed Score  80.50

PubMed score by year
PubTator Score  463.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer