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Tbio
QRSL1
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

Protein Summary
Description
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369046
  • ENSP00000358042
  • ENSG00000130348

Symbol
  • GatA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
kinase perturbation
0.96
histone modification site profile
0.91
molecular function
0.86
transcription factor perturbation
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.6   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.6   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
GATC
Tbio
Family:  Enzyme
Novelty:  0.62484697
p_int:  1
Score:  0.983
Data Source:  BioPlex,STRINGDB
GPBP1L1
Tdark
Novelty:  0.69320833
p_int:  0.999999996
p_ni:  4e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
GATB
Tbio
Family:  Enzyme
Novelty:  0.01269151
p_int:  0.999999329
p_ni:  6.71e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
APOA2
Tbio
Novelty:  0.00117627
p_int:  0.946660553
p_ni:  0.022746433
p_wrong:  0.030593015
Data Source:  BioPlex
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.942413045
p_ni:  0.056827086
p_wrong:  0.000759869
Data Source:  BioPlex
ARSG
Tbio
Family:  Enzyme
Novelty:  0.04412917
p_int:  0.930177282
p_ni:  0.069822718
Score:  0.206
Data Source:  BioPlex,STRINGDB
NARS2
Tbio
Family:  Enzyme
Novelty:  0.01879317
Score:  0.982
Data Source:  STRINGDB
QARS
Tchem
Family:  Enzyme
Novelty:  0.01684657
Score:  0.972
Data Source:  STRINGDB
NARS
Tbio
Family:  Enzyme
Novelty:  0.01124207
Score:  0.969
Data Source:  STRINGDB
EARS2
Tbio
Family:  Enzyme
Novelty:  0.00280518
Score:  0.83
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
46.5
urate measurement
1
1
1
37.6
blood urea nitrogen measurement
1
1
1
17.8
glomerular filtration rate
1
1
0
5.5
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
46.5
urate measurement
1
37.6
blood urea nitrogen measurement
1
17.8
glomerular filtration rate
0
5.5
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
462909
Macaque
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
697354
Mouse
MGI:1923813
76563
Rat
RGD:1359490
309911
Dog
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
475014
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Macaque
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Mouse
Rat
Dog
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Publication Statistics
PubMed Score 126.60
PubMed score by year
PubTator Score 463.16
PubTator score by year
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Related Publications
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PMID
Year
Title