Pharos : Target Details

Tbio

Protein Classes

Protein Summary

Description

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

Uniprot Accession IDs

Gene Name

QRSL1

Ensembl ID

ENST00000369046
ENSP00000358042
ENSG00000130348

Symbol

GatA

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97

kinase perturbation	0.96

histone modification site profile	0.91

molecular function	0.86

transcription factor perturbation	0.74

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.5 (req: < 5)

View Publications

Gene RIFs: 3 (req: <= 3)

View Gene RIFs

Antibodies: 144 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.5 (req: >= 5)

Gene RIFs: 3 (req: > 3)

Antibodies: 144 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (3)

KEGG (2)

PathwayCommons (1)

Items per page:

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Aminoacyl-tRNA biosynthesis	44 targets	path:hsa00970

KEGG	Metabolic pathways	1433 targets	path:hsa01100

Name	Explore in Pharos	Explore in Source
Aminoacyl-tRNA biosynthesis	44 targets	path:hsa00970

Metabolic pathways	1433 targets	path:hsa01100

Gene Ontology Terms (8)

Functions (3)

Components (2)

Processes (3)

Items per page:

1 – 3 of 3

GO Term	Evidence	Assigned by
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Inferred from Direct Assay (IDA)	UniProtKB

amidase activity	Inferred from Electronic Annotation (IEA)	InterPro

ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (75)

1 – 10 of 75

See Interactions on String-DB

GATC

Tbio

Family: Enzyme

p_int: 1

Score: 0.983

Data Source: BioPlex,STRINGDB

GPBP1L1

Tdark

Novelty: 0.23809524

p_int: 0.999999996

p_ni: 4e-9

Score: 0.185

Data Source: BioPlex,STRINGDB

GATB

Tbio

Family: Enzyme

Novelty: 0.0265185

p_int: 0.999999329

p_ni: 6.71e-7

Score: 0.999

Data Source: BioPlex,STRINGDB

APOA2

Tbio

Novelty: 0.00133324

p_int: 0.946660553

p_ni: 0.022746433

p_wrong: 0.030593015

Data Source: BioPlex

USP47

Tchem

Family: Enzyme

Novelty: 0.12618297

p_int: 0.942413045

p_ni: 0.056827086

p_wrong: 0.000759869

Data Source: BioPlex

ARSG

Tbio

Family: Enzyme

Novelty: 0.0408666

p_int: 0.930177282

p_ni: 0.069822718

Score: 0.206

Data Source: BioPlex,STRINGDB

NARS2

Tbio

Family: Enzyme

Novelty: 0.02380757

Score: 0.982

Data Source: STRINGDB

QARS

Tchem

Family: Enzyme

Novelty: 0.02294313

Score: 0.972

Data Source: STRINGDB

NARS

Tbio

Family: Enzyme

Novelty: 0.00941326

Score: 0.969

Data Source: STRINGDB

EARS2

Tbio

Family: Enzyme

Novelty: 0.00399418

Score: 0.83

Data Source: STRINGDB

Publication Statistics

PubMed Score 80.50

PubMed score by year

PubTator Score 463.16

PubTator score by year

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword


Alternative splicing

ATP-binding

Complete proteome

Disease mutation

Ligase

Mitochondrion

Nucleotide-binding

Polymorphism

Protein biosynthesis

Reference proteome

GWAS Trait