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Tbio
FXYD6
FXYD domain-containing ion transport regulator 6

Protein Summary
Description
This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260282
  • ENSP00000260282
  • ENSG00000137726
  • ENST00000524656
  • ENSP00000431427
  • ENST00000526014
  • ENSP00000433312
  • ENST00000527717
  • ENSP00000431446
  • ENST00000530956
  • ENSP00000463158
  • ENST00000539526
  • ENSP00000442756
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.87
gene perturbation
0.85
transcription factor perturbation
0.8
tissue sample
0.64
tissue
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.37   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.37   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Myopia
2
2
0
4.3
71.8
refractive error measurement
2
2
1
7.5
71.8
age at onset
1
1
0
7.5
59.9
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Myopia
0
4.3
71.8
refractive error measurement
1
7.5
71.8
age at onset
0
7.5
59.9
1
30.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FXYD domain containing ion transport regulator 6
VGNC:50381
451579
Mouse
MGI:1890226
59095
Rat
RGD:69315
63847
Dog
FXYD domain containing ion transport regulator 6
610831
Horse
FXYD domain containing ion transport regulator 6
100062824
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FXYD domain containing ion transport regulator 6
Mouse
Rat
Dog
FXYD domain containing ion transport regulator 6
Horse
FXYD domain containing ion transport regulator 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H0Q3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Muscle contraction
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (44)
1 – 10 of 44
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.999919243
p_ni:  0.000028334
p_wrong:  0.000052423
Score:  0.254
Data Source:  BioPlex,STRINGDB
TSPAN31
Tbio
Novelty:  0.13580467
p_int:  0.999511943
p_ni:  0.000408032
p_wrong:  0.000080025
Data Source:  BioPlex
ATR
Tchem
Family:  Kinase
Novelty:  0.00196978
p_int:  0.999475451
p_ni:  0.000524549
Data Source:  BioPlex
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.990399955
p_ni:  0.009600045
Data Source:  BioPlex
DNM3
Tbio
Novelty:  0.02365643
p_int:  0.988765907
p_ni:  0.011233927
p_wrong:  1.66e-7
Data Source:  BioPlex
ATRIP
Tbio
Novelty:  0.01415267
p_int:  0.987886372
p_ni:  0.011950425
p_wrong:  0.000163203
Data Source:  BioPlex
COLEC12
Tbio
Novelty:  0.02882427
p_int:  0.985097215
p_ni:  0.01310567
p_wrong:  0.001797115
Data Source:  BioPlex
BRAT1
Tbio
Novelty:  0.04039173
p_int:  0.975670539
p_ni:  0.024329461
Data Source:  BioPlex
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.959807892
p_ni:  0.000026851
p_wrong:  0.040165257
Score:  0.186
Data Source:  BioPlex,STRINGDB
CIP2A
Tbio
Novelty:  0.00992381
p_int:  0.952485952
p_ni:  0.047514048
Data Source:  BioPlex
Publication Statistics
PubMed Score  22.37

PubMed score by year
PubTator Score  12.6

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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