You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NT5C3A
Cytosolic 5'-nucleotidase 3A

Protein Summary
Description
Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed:24603684). CMP seems to be the preferred substrate (PubMed:15968458). This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381626
  • ENSP00000371039
  • ENSG00000122643
  • ENST00000396152
  • ENSP00000379456
  • ENST00000405342
  • ENSP00000385261
  • ENST00000409467
  • ENSP00000387166
  • ENST00000620705
  • ENSP00000484415
  • ENST00000643244
  • ENSP00000496364

Symbol
  • NT5C3
  • P5N1
  • UMPH1
  • p36
  • PN-I
  • POMP
  • PSN1
  • UMPH
  • NT5C3
  • P5N-1
  • UMPH1
  • hUMP1
  • P5'N-1
  • cN-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
kinase perturbation
0.84
histone modification site profile
0.79
transcription factor
0.72
molecular function
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.91   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.91   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0