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Tbio
NT5C3A
Cytosolic 5'-nucleotidase 3A

Protein Summary
Description
Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed:24603684). CMP seems to be the preferred substrate (PubMed:15968458). This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381626
  • ENSP00000371039
  • ENSG00000122643
  • ENST00000396152
  • ENSP00000379456
  • ENST00000405342
  • ENSP00000385261
  • ENST00000409467
  • ENSP00000387166
  • ENST00000620705
  • ENSP00000484415
  • ENST00000643244
  • ENSP00000496364

Symbol
  • NT5C3
  • P5N1
  • UMPH1
  • p36
  • PN-I
  • POMP
  • PSN1
  • UMPH
  • NT5C3
  • P5N-1
  • UMPH1
  • hUMP1
  • P5'N-1
  • cN-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
kinase perturbation
0.84
histone modification site profile
0.79
transcription factor
0.72
molecular function
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.58   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.58   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
2
4
92.8
mean corpuscular volume
1
1
1
32.9
glomerular filtration rate
1
1
1
30.6
mean reticulocyte volume
1
1
1
14.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
92.8
mean corpuscular volume
1
32.9
glomerular filtration rate
1
30.6
mean reticulocyte volume
1
14.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
5'-nucleotidase, cytosolic IIIA
708743
Mouse
MGI:1927186
107569
Dog
5'-nucleotidase, cytosolic IIIA
VGNC:43997
475277
Horse
5'-nucleotidase, cytosolic IIIA
VGNC:20914
100055382
Cow
5'-nucleotidase, cytosolic IIIA
VGNC:32292
511858
Species
Name
OMA
EggNOG
Inparanoid
Macaque
5'-nucleotidase, cytosolic IIIA
Mouse
Dog
5'-nucleotidase, cytosolic IIIA
Horse
5'-nucleotidase, cytosolic IIIA
Cow
5'-nucleotidase, cytosolic IIIA
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H0P0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (31)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Pyrimidine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Pyrimidine catabolism
Protein-Protein Interactions (152)
1 – 10 of 152
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.999983728
p_ni: 0.000016272
Data Source: BioPlex
GHITM
Tbio
Novelty: 0.00360652
p_int: 0.999944262
p_ni: 0.000055738
Data Source: BioPlex
SLC6A1
Tclin
Family: Transporter
Novelty: 0.00165116
p_int: 0.999573188
p_ni: 0.000426812
Data Source: BioPlex
BZW2
Tbio
Novelty: 0.17006204
p_int: 0.999187747
p_ni: 0.000812253
Data Source: BioPlex
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.99791765
p_ni: 0.00208228
p_wrong: 7e-8
Data Source: BioPlex
FAM86C1
Tdark
Family: Enzyme
Novelty: 1.61781609
p_int: 0.987565054
p_ni: 0.012431724
p_wrong: 0.000003222
Data Source: BioPlex
SLC39A12
Tbio
Family: Transporter
Novelty: 0.09127395
p_int: 0.980674967
p_ni: 0.019324956
p_wrong: 7.6e-8
Data Source: BioPlex
SLC39A4
Tbio
Family: Transporter
Novelty: 0.00742159
p_int: 0.978030156
p_ni: 0.021969824
p_wrong: 2e-8
Data Source: BioPlex
GPC3
Tbio
Novelty: 0.00151823
p_int: 0.975175597
p_ni: 0.024814707
p_wrong: 0.000009695
Data Source: BioPlex
KCNA5
Tclin
Family: IC
Novelty: 0.00182891
p_int: 0.974445282
p_ni: 0.025474615
p_wrong: 0.000080104
Data Source: BioPlex
Publication Statistics
PubMed Score  48.58

PubMed score by year
PubTator Score  644.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer