Tbio PCBD2 Pterin-4-alpha-carbinolamine dehydratase 2

Protein Summary

Description

Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.

Uniprot Accession IDs

• Q9H0N5
• Q8TD40
• PHS 2

Gene Name

• PCBD2

Ensembl ID

• ENST00000254908
• ENSP00000254908
• ENSG00000132570
• ENST00000512783
• ENSP00000421544

Symbol

• DCOH2
• DCOHM
• PHS2
• DCOH2
• DCOHM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
histone modification site profile	0.87
transcription factor binding site profile	0.81
cell type or tissue	0.74
virus perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Lyase / Dehydratase / Pterin-4-alpha-carbinolamine Dehydratase 2

DTO Classes

Protein / Enzyme / Lyase / Dehydratase / Pterin-4-alpha-carbinolamine Dehydratase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.72   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 55   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.72   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0