You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PCBD2
Pterin-4-alpha-carbinolamine dehydratase 2

Protein Summary
Description
Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254908
  • ENSP00000254908
  • ENSG00000132570
  • ENST00000512783
  • ENSP00000421544

Symbol
  • DCOH2
  • DCOHM
  • PHS2
  • DCOH2
  • DCOHM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.87
transcription factor binding site profile
0.81
cell type or tissue
0.74
virus perturbation
0.72


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.72   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.72   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0