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Tbio
WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265428
  • ENSP00000265428
  • ENSG00000123124
  • ENST00000517970
  • ENSP00000427793

Symbol
  • AIP5
  • Tiul1
  • hSDRP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
disease perturbation
0.74
transcription factor perturbation
0.74
cellular component
0.71
virus perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.21   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.21   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
visceral adipose tissue measurement
1
1
1
74.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
visceral adipose tissue measurement
1
74.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WW domain containing E3 ubiquitin protein ligase 1
VGNC:759
464269
Mouse
MGI:1861728
107568
Rat
RGD:1311734
297930
Dog
WW domain containing E3 ubiquitin protein ligase 1
VGNC:48443
100856769
Horse
WW domain containing E3 ubiquitin protein ligase 1
VGNC:25060
100055725
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WW domain containing E3 ubiquitin protein ligase 1
Mouse
Rat
Dog
WW domain containing E3 ubiquitin protein ligase 1
Horse
WW domain containing E3 ubiquitin protein ligase 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H0M0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (170)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Downregulation of ERBB4 signaling
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Downregulation of ERBB4 signaling
Gene expression (Transcription)
Protein-Protein Interactions (416)
1 – 10 of 416
FAM189B
Tbio
Novelty: 0.21064304
p_int: 0.998609913
p_ni: 0.001390087
Score: 0.203
Data Source: BioPlex,STRINGDB
CUEDC1
Tbio
Novelty: 0.14401061
p_int: 0.997399853
p_ni: 0.002600147
Data Source: BioPlex
WBP1
Tbio
Novelty: 1.24967974
p_int: 0.990179755
p_ni: 0.009820245
Score: 0.361
Data Source: BioPlex,STRINGDB
FAM189A2
Tdark
Novelty: 0.41335428
p_int: 0.987558383
p_ni: 0.012441617
Score: 0.232
Data Source: BioPlex,STRINGDB
ARRDC3
Tbio
Novelty: 0.04840692
p_int: 0.984209799
p_ni: 0.015790201
Score: 0.742
Data Source: BioPlex,STRINGDB
TMEM255A
Tdark
Novelty: 1.03700118
p_int: 0.98306597
p_ni: 0.01693403
Score: 0.193
Data Source: BioPlex,STRINGDB
TMEM51
Tdark
Novelty: 0.54147214
p_int: 0.981949938
p_ni: 0.018050062
Data Source: BioPlex
SPART
Tbio
Novelty: 0.01524727
p_int: 0.980780736
p_ni: 0.019219264
Score: 0.653
Data Source: BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty: 0.04881486
p_int: 0.956276267
p_ni: 0.043723733
Score: 0.21
Data Source: BioPlex,STRINGDB
TMEM255B
Tdark
Novelty: 1.57149427
p_int: 0.945034663
p_ni: 0.054965337
Score: 0.345
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  79.21

PubMed score by year
PubTator Score  42.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer