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Tbio
WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265428
  • ENSP00000265428
  • ENSG00000123124
  • ENST00000517970
  • ENSP00000427793

Symbol
  • AIP5
  • Tiul1
  • hSDRP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
disease perturbation
0.74
transcription factor perturbation
0.74
cellular component
0.71
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.96   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.96   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (170)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Downregulation of ERBB4 signaling
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Downregulation of ERBB4 signaling
Gene expression (Transcription)
Protein-Protein Interactions (416)
1 – 10 of 416
FAM189B
Tbio
Novelty: 0.62780269
p_int: 0.998609913
p_ni: 0.001390087
Score: 0.203
Data Source: BioPlex,STRINGDB
CUEDC1
Tdark
Novelty: 0.26785714
p_int: 0.997399853
p_ni: 0.002600147
Data Source: BioPlex
WBP1
Tbio
Novelty: 4
p_int: 0.990179755
p_ni: 0.009820245
Score: 0.361
Data Source: BioPlex,STRINGDB
FAM189A2
Tdark
Novelty: 1.62162162
p_int: 0.987558383
p_ni: 0.012441617
Score: 0.232
Data Source: BioPlex,STRINGDB
ARRDC3
Tbio
Novelty: 0.06803495
p_int: 0.984209799
p_ni: 0.015790201
Score: 0.742
Data Source: BioPlex,STRINGDB
TMEM255A
Tdark
p_int: 0.98306597
p_ni: 0.01693403
Score: 0.193
Data Source: BioPlex,STRINGDB
TMEM51
Tdark
Novelty: 1.41176471
p_int: 0.981949938
p_ni: 0.018050062
Data Source: BioPlex
SPART
Tbio
Novelty: 0.01341821
p_int: 0.980780736
p_ni: 0.019219264
Score: 0.653
Data Source: BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty: 0.02672907
p_int: 0.956276267
p_ni: 0.043723733
Score: 0.21
Data Source: BioPlex,STRINGDB
TMEM255B
Tdark
Novelty: 1
p_int: 0.945034663
p_ni: 0.054965337
Score: 0.345
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  59.96

PubMed score by year
PubTator Score  42.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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