Tbio CSTF2T Cleavage stimulation factor subunit 2 tau variant

Protein Summary

Description

May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity).

Uniprot Accession IDs

• Q9H0L4
• B2RAR9
• O75174
• Q53HK6
• Q7LGE8
• Q8N6T1

Gene Name

• CSTF2T

Ensembl ID

• ENST00000331173
• ENSP00000332444
• ENSG00000177613

Symbol

• KIAA0689
• CstF-64T

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
disease perturbation	0.9
virus perturbation	0.9
transcription factor binding site profile	0.88
histone modification site profile	0.8

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Cleavage Stimulation Factor Subunit 2 Tau Variant

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Cleavage Stimulation Factor Subunit 2 Tau Variant

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.99   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.99   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (241)

Explore Interacting Targets

1 – 10 of 241

• See Interactions on String-DB

CSTF3

Tbio

Novelty:  0.05260909

p_int:  0.999999998

p_ni:  2e-9

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

CSTF2

Tbio

Novelty:  0.01389909

p_int:  0.999999961

p_ni:  3.9e-8

Score:  0.988

Data Source:  BioPlex,STRINGDB

CSTF1

Tbio

Novelty:  0.08711712

p_int:  0.999999775

p_ni:  1.57e-7

p_wrong:  6.8e-8

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

SYMPK

Tbio

Novelty:  0.01773552

p_int:  0.999949385

p_ni:  0.000050614

p_wrong:  1e-9

Score:  0.994

Data Source:  BioPlex,STRINGDB

BIRC2

Tchem

Novelty:  0.00199701

p_int:  0.993715602

p_ni:  0.006284398

Score:  0.151

Data Source:  BioPlex,STRINGDB

CLINT1

Tbio

Novelty:  0.00945381

p_int:  0.992242443

p_ni:  0.007757528

p_wrong:  2.9e-8

Data Source:  BioPlex

CRTAP

Tbio

Novelty:  0.02380647

p_int:  0.991074611

p_ni:  0.008925389

Score:  0.416

Data Source:  BioPlex,STRINGDB

CRYAA

Tchem

Novelty:  0.01914081

p_int:  0.990913988

p_ni:  0.008636504

p_wrong:  0.000449507

Data Source:  BioPlex

CPEB1

Tbio

Novelty:  0.00444378

p_int:  0.990658461

p_ni:  0.009340764

p_wrong:  7.75e-7

Score:  0.822

Data Source:  BioPlex,STRINGDB

ZNF571

Tdark

Family:  TF

Novelty:  58

p_int:  0.988349588

p_ni:  0.011063641

p_wrong:  0.000586771

Score:  0.329

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (12)

Reactome (10)

KEGG (1)

WikiPathways (1)

Gene expression (Transcription) (R-HSA-74160)

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Find Similar Targets

Items per page:

5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	Processing of Capped Intronless Pre-mRNA	28 targets	R-HSA-75067
Reactome	Processing of Intronless Pre-mRNAs	19 targets	R-HSA-77595

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Processing of Capped Intronless Pre-mRNA	28 targets	R-HSA-75067
Processing of Intronless Pre-mRNAs	19 targets	R-HSA-77595

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (2)

Components (3)

Processes (4)

Find Similar Targets

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
mRNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1	1	1		14.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1		14.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
mRNA processing
Nucleus
Phosphoprotein
Reference proteome
Repeat
RNA-binding

GWAS Trait Find Similar Targets

No Header	No Header
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	cleavage stimulation factor, 3' pre-RNA subunit 2, tau	MGI:1932622	83410
Rat	cleavage stimulation factor subunit 2, tau variant	RGD:1310026	309338
Horse	cleavage stimulation factor subunit 2 tau variant	VGNC:16921	100062520
Cow	cleavage stimulation factor subunit 2 tau variant	VGNC:27782	783569
Pig	cleavage stimulation factor subunit 2 tau variant		100157243

Species	Name	OMA	EggNOG	Inparanoid
Mouse	cleavage stimulation factor, 3' pre-RNA subunit 2, tau
Rat	cleavage stimulation factor subunit 2, tau variant
Horse	cleavage stimulation factor subunit 2 tau variant
Cow	cleavage stimulation factor subunit 2 tau variant
Pig	cleavage stimulation factor subunit 2 tau variant

Publication Statistics

PubMed Score 11.99

PubMed score by year

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PubTator Score 3.19

PubTator score by year

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Related Publications

Text Mined References (24)

GeneRif Annotations (7)

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10

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PMID	Year	Title