You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SIK2
Serine/threonine-protein kinase SIK2

Protein Summary
Description
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304987
  • ENSP00000305976
  • ENSG00000170145

Symbol
  • KIAA0781
  • QIK
  • SNF1LK2
  • QIK
  • SIK-2
  • SNF1LK2
  • LOH11CR1I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
molecular function
0.95
protein domain
0.92
virus perturbation
0.92
interacting protein
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.52   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.52   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2