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Tbio
PARP12
Poly [ADP-ribose] polymerase 12

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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.69   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.69   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
2
39.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
39.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 12
VGNC:4456
463776
Macaque
poly(ADP-ribose) polymerase family member 12
711660
Mouse
MGI:2143990
243771
Rat
RGD:1308628
362343
Dog
poly(ADP-ribose) polymerase family member 12
VGNC:51818
482770
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 12
Macaque
poly(ADP-ribose) polymerase family member 12
Mouse
Rat
Dog
poly(ADP-ribose) polymerase family member 12
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H0J9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (76)
1 – 10 of 76
BHLHA15
Tbio
Family: TF
Novelty: 0.02721846
p_int: 0.999945525
p_ni: 0.000054475
Data Source: BioPlex
RNF166
Tdark
Novelty: 0.71460884
p_int: 0.999684542
p_ni: 0.00022912
p_wrong: 0.000086338
Score: 0.538
Data Source: BioPlex,STRINGDB
GCLM
Tbio
Family: Enzyme
Novelty: 0.00395815
p_int: 0.998023847
p_ni: 0.001963499
p_wrong: 0.000012654
Score: 0.197
Data Source: BioPlex,STRINGDB
MKRN2
Tbio
Family: Enzyme
Novelty: 0.14061051
p_int: 0.988298437
p_ni: 0.011701533
p_wrong: 2.9e-8
Score: 0.395
Data Source: BioPlex,STRINGDB
RNF114
Tbio
Family: Enzyme
Novelty: 0.06758257
p_int: 0.987384483
p_ni: 0.012615517
Score: 0.694
Data Source: BioPlex,STRINGDB
PARP9
Tbio
Family: Enzyme
Novelty: 0.02702134
Score: 0.907
Data Source: STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.828
Data Source: STRINGDB
RSAD2
Tbio
Novelty: 0.0056473
Score: 0.824
Data Source: STRINGDB
ISG15
Tbio
Novelty: 0.00203781
Score: 0.816
Data Source: STRINGDB
OAS2
Tbio
Family: Enzyme
Novelty: 0.01673393
Score: 0.8
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.69

PubMed score by year
PubTator Score  21.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer